Evidence map›Paper›PMID 28138972›Full record

ArticleJournal of applied toxicology : JAT2017

Glaucarubulone glucoside from Castela macrophylla suppresses MCF-7 breast cancer cell growth and attenuates benzo[a]pyrene-mediated CYP1A gene induction.

Simone A M Badal, Malyn M Asuncion Valenzuela, Dain Zylstra, George Huang, Pallavi Vendantam, Sheena Francis, Ashley Quitugua, Louisa H Amis, Willie Davis, Tzuen-Rong J Tzeng and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of applied toxicology : JAT, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Quassinoids as Promising Anti-cancer Agents.Current medicinal chemistry · 2025
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 7 institutions in 3 countries.

Simone A M BadalNatural Products Institute, Faculty of Science and Technology, University of the West Indies, Mona, Jamaica, West Indies.
Malyn M Asuncion ValenzuelaDepartment of Basic Sciences, Center for Health Disparities and Molecular Medicine, Loma Linda University Health School of Medicine, Loma Linda, CA, 92350, USA.
Dain ZylstraDepartment of Pharmaceutical and Administrative Sciences, Loma Linda University Health School of Pharmacy, Loma Linda, CA, 92350, USA.
George HuangDepartment of Biological Sciences, Clemson University, Clemson, SC, 29634, USA.
Pallavi VendantamDepartment of Biological Sciences, Clemson University, Clemson, SC, 29634, USA.
Sheena FrancisNatural Products Institute, Faculty of Science and Technology, University of the West Indies, Mona, Jamaica, West Indies.
Ashley QuituguaDepartment of Pharmaceutical and Administrative Sciences, Loma Linda University Health School of Pharmacy, Loma Linda, CA, 92350, USA.
Louisa H AmisDepartment of Basic Sciences, Center for Health Disparities and Molecular Medicine, Loma Linda University Health School of Medicine, Loma Linda, CA, 92350, USA.
Willie DavisDepartment of Basic Sciences, Center for Health Disparities and Molecular Medicine, Loma Linda University Health School of Medicine, Loma Linda, CA, 92350, USA.
Tzuen-Rong J TzengDepartment of Biological Sciences, Clemson University, Clemson, SC, 29634, USA.
Helen JacobsDepartment of Chemistry, Faculty of Science and Technology, University of the West Indies, Mona, Jamaica, West Indies.
David J GangemiDepartment of Biological Sciences, Clemson University, Clemson, SC, 29634, USA.
Greg RanerDepartment of Chemistry and Biochemistry, The University of North Carolina at Greensboro, Greensboro, NC, 27402, USA.
Leah RowlandDepartment of Basic Sciences, Center for Health Disparities and Molecular Medicine, Loma Linda University Health School of Medicine, Loma Linda, CA, 92350, USA.
Jonathan WootenDepartment of Basic Sciences, Center for Health Disparities and Molecular Medicine, Loma Linda University Health School of Medicine, Loma Linda, CA, 92350, USA.
Petreena CampbellDepartment of Basic Sciences, Center for Health Disparities and Molecular Medicine, Loma Linda University Health School of Medicine, Loma Linda, CA, 92350, USA.
Eileen BrantleyDepartment of Basic Sciences, Center for Health Disparities and Molecular Medicine, Loma Linda University Health School of Medicine, Loma Linda, CA, 92350, USA.
Rupika DelgodaNatural Products Institute, Faculty of Science and Technology, University of the West Indies, Mona, Jamaica, West Indies.
Clemson University · USLoma Linda University · USLoma Linda University Health Care · USUniversity of the West Indies · BSUniversity of the West Indies System · JMLiberty University · USUniversity of California, Riverside · US

Funding

NIH-LLU Initiative for Maximizing Student DiversityR25GM060507 · NIGMS · LOMA LINDA UNIVERSITY · PI DE LEON, MARINO · 2001 to 2022
$11.3M
Research Training/Education CoreP20MD006988 · NIMHD · LOMA LINDA UNIVERSITY · PI DE LEON, MARINO · 2012 to 2016
$6.2M
Oxidative DNA Damage and CpG MutagenesisR01CA101864 · NCI · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI WANG, YINSHENG · 2004 to 2015
$2.8M
Antioxidant activities of freeze dried acai berry (Euterpe Oleracea)extractsR15AT007860 · NCCIH · UNIVERSITY OF NORTH CAROLINA GREENSBORO · PI RANER, GREGORY M · 2013 to 2013
$388k
NCCIH NIH HHS R15 AT007860NCI NIH HHS R01 CA101864NIGMS NIH HHS R25 GM060507NIMHD NIH HHS P20 MD006988
6 · The paper itself

Abstract

Quassinoids often exhibit antioxidant and antiproliferative activity. Emerging evidence suggests that these natural metabolites also display chemopreventive actions. In this study, we investigated the potential for the quassinoid glaucarubulone glucoside (Gg), isolated from the endemic Jamaican plant Castela macrophylla (Simaroubaceae), to display potent cytotoxicity and inhibit human cytochrome P450s (CYPs), particularly CYP1A enzymes, known to convert polyaromatic hydrocarbons into carcinogenic metabolites. Gg reduced the viability of MCF-7 breast adenocarcinoma cells (IC

Indexed as

Antineoplastic Agents, PhytogenicAntioxidantsBreast NeoplasmsCell Line, TumorCell ProliferationCytochrome P-450 Enzyme SystemCytotoxinsFemaleGene ExpressionGlaucarubinHumansJamaicaMCF-7 CellsPlant ExtractsQuassinsSimaroubaceaeAntineoplastic Agents, PhytogenicAntioxidantsCytochrome P-450 Enzyme SystemCytotoxinsGlaucarubinglaucarubolonePlant ExtractsQuassinsbreast cancerchemopreventioncytochrome P450cytotoxicitynatural product

Identifiers

PMID28138972
PMCPMC5435539
OpenAlexW2585207324

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.