ArticleBritish journal of pharmacology2017
Role of inducible nitric oxide synthase in endothelium-independent relaxation to raloxifene in rat aorta.
Article in British journal of pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- Pharmacotherapeutic considerations of selective estrogen receptor modulators for vascular protection.Frontiers in pharmacology · 2026Review
- Effects of 17β-Estradiol Treatment on Metabolic Function and Aortic Relaxation in Castrated Male Rats.International journal of molecular sciences · 2025Article
- Discovery of a Bradykinin B2 Partial Agonist Profile of Raloxifene in a Drug Repurposing Campaign.International journal of molecular sciences · 2020Article
- Article
- Bazedoxifene-induced vasodilation and inhibition of vasoconstriction is significantly greater than estradiol.Menopause (New York, N.Y.) · 2019Article
- Estrogen relaxes gastric muscle cells via a nitric oxide- and cyclic guanosine monophosphate-dependent mechanism: A sex-associated differential effect.Experimental and therapeutic medicine · 2018Article
- Rapid vasodilation to raloxifene: role of oestrogen receptors and off-target effects.British journal of pharmacology · 2017Article
- Role of inducible nitric oxide synthase in endothelium-independent relaxation to raloxifene in rat aorta.British journal of pharmacology · 2017Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeRaloxifene can induce both endothelium-dependent and -independent relaxation in different arteries. However, the underlying mechanisms by which raloxifene triggers endothelium-independent relaxation are still incompletely understood. The purpose of present study was to examine the roles of NOSs and Ca EXPERIMENTAL APPROACH: Changes in isometric tension, cGMP, nitrite, inducible NOS protein expression and distribution in response to raloxifene in endothelium-denuded aortic rings were studied by organ baths, radioimmunoassay, Griess reaction, western blot and immunohistochemistry respectively. KEY
resultsRaloxifene reduced the contraction to CaCl CONCLUSIONS AND IMPLICATIONS: Raloxifene-mediated vasorelaxation in rat aorta is independent of a functional endothelium and is mediated by oestrogen receptors and NF-κB. This effect is mainly mediated through an enhanced production of NO, cGMP and nitrite, via the induction of iNOS and inhibition of calcium influx through Ca
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