Evidence map›Paper›PMID 28138953›Full record

ArticleHigh blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension2017

Clinical Benefits of Unilateral Adrenalectomy in Patients with Subclinical Hypercortisolism Due to Adrenal Incidentaloma: Results from a Single Center.

Luigi Petramala, Giuseppe Cavallaro, Matteo Galassi, Cristiano Marinelli, Gianfranco Tonnarini, Antonio Concistrè, Umberto Costi, Maurizio Bufi, Piernatale Lucia, Giuseppe De Vincentis and 3 more

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Article in High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.

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  16. Endocrine Tumors Causing Arterial Hypertension: Pathophysiological Mechanisms and Clinical Implications.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2017
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Luigi PetramalaDepartment of Internal Medicine and Medical Specialties, Specialized Center of Secondary Hypertension, University of Rome "Sapienza", Viale del Policlinico, 155, 00161, Rome, Italy.
Giuseppe CavallaroDepartment of Surgery "P. Valdoni", University of Rome, "Sapienza", Rome, Italy.
Matteo GalassiDepartment of Internal Medicine and Medical Specialties, Specialized Center of Secondary Hypertension, University of Rome "Sapienza", Viale del Policlinico, 155, 00161, Rome, Italy.
Cristiano MarinelliDepartment of Internal Medicine and Medical Specialties, Specialized Center of Secondary Hypertension, University of Rome "Sapienza", Viale del Policlinico, 155, 00161, Rome, Italy.
Gianfranco TonnariniDepartment of Internal Medicine and Medical Specialties, Specialized Center of Secondary Hypertension, University of Rome "Sapienza", Viale del Policlinico, 155, 00161, Rome, Italy.
Antonio ConcistrèDepartment of Internal Medicine and Medical Specialties, Specialized Center of Secondary Hypertension, University of Rome "Sapienza", Viale del Policlinico, 155, 00161, Rome, Italy.
Umberto CostiDepartment of Surgery "P. Valdoni", University of Rome, "Sapienza", Rome, Italy.
Maurizio BufiDepartment of Surgery "P. Valdoni", University of Rome, "Sapienza", Rome, Italy.
Piernatale LuciaDepartment of Internal Medicine and Medical Specialties, Specialized Center of Secondary Hypertension, University of Rome "Sapienza", Viale del Policlinico, 155, 00161, Rome, Italy.
Giuseppe De VincentisNuclear Medicine Section, Department of Radiology, University of Rome, "Sapienza", Rome, Italy.
Gino IannucciDepartment of Internal Medicine and Medical Specialties, Specialized Center of Secondary Hypertension, University of Rome "Sapienza", Viale del Policlinico, 155, 00161, Rome, Italy.
Giorgio De TomaDepartment of Surgery "P. Valdoni", University of Rome, "Sapienza", Rome, Italy.
Claudio LetiziaDepartment of Internal Medicine and Medical Specialties, Specialized Center of Secondary Hypertension, University of Rome "Sapienza", Viale del Policlinico, 155, 00161, Rome, Italy. claudio.letizia@uniroma1.it.ORCID http://orcid.org/0000-0003-4397-0624
Policlinico Umberto I · ITSapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThis study was designed to evaluate the results of unilateral laparoscopic adrenalectomy in patients with subclinical hypercortisolism (SH) due to adrenal incidentaloma (AI) concerning the main cardiometabolic disorders.

methodsWe have studied between January 2000 to December 2015, 645 patients with AI (283 males and 362 females; mean age 61.9 ± 10 years) and we found 70 patients with SH (27 males and 43 females; mean age 61.9 ± 8.4 years). Twenty-six (37%) SH patients (6 males and 20 females; mean age 58.7 ± 7.1 years) underwent unilateral laparoscopic adrenalectomy, whereas 44 SH patients (21 males and 23 females; mean age 63.9 ± 9.9 years) performed a conservative treatment. All SH patients were evaluated at diagnosis and after follow-up (mean 12 months; range 9-15 months).

resultsIn only SH patients undergoing unilateral adrenalectomy we found a statistical significant reduction of the arterial hypertension and metabolic syndrome (p < 0.05, respectively). In particular we observed a reduction of 24-h systolic blood pressure and "non-dipper" pattern (p < 0.05, respectively) evaluated with ambulatory blood pressure monitoring (ABPM).

conclusionsOur study confirm the high prevalence of SH in AI, and the unilateral laparoscopic adrenalectomy seemed to have a beneficial effect on some cardiometabolic disorders.

Indexed as

Arterial PressureIncidental FindingsLaparoscopyAdrenalectomyAdrenal Gland DiseasesAgedAntihypertensive AgentsAsymptomatic DiseasesBlood Pressure Monitoring, AmbulatoryCircadian RhythmCushing SyndromeFemaleHumansHypertensionMaleMiddle AgedAntihypertensive AgentsAmbulatory blood pressure monitoringCardiometabolic disordersSubclinical hypercortisolism due to adrenal incidentalomaUnilateral laparoscopy adrenalectomy

Identifiers

PMID28138953
OpenAlexW2582901977

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.