Evidence map›Paper›PMID 28138813›Full record

ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2017

Noninvasive PET quantitative myocardial blood flow with regadenoson for assessing cardiac allograft vasculopathy in orthotopic heart transplantation patients.

Miguel Hernandez Pampaloni, Uttam M Shrestha, Maria Sciammarella, Youngho Seo, Grant T Gullberg, Elias H Botvinick

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In one paragraph

Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Quantitative myocardial perfusion response to adenosine and regadenoson in patients with suspected coronary artery disease.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Regadenoson-induced hyperemia for absolute myocardial blood flow quantitation byJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Miguel Hernandez PampaloniDepartment of Radiology and Biomedical Imaging, University of California, 185 Berry St., Suite 350, San Francisco, CA, 94143-0946, USA.
Uttam M ShresthaDepartment of Radiology and Biomedical Imaging, University of California, 185 Berry St., Suite 350, San Francisco, CA, 94143-0946, USA. uttam.shrestha@ucsf.edu.
Maria SciammarellaDivision of Cardiology, Department of Medicine, University of California, San Francisco, CA, USA.
Youngho SeoDepartment of Radiology and Biomedical Imaging, University of California, 185 Berry St., Suite 350, San Francisco, CA, 94143-0946, USA.
Grant T GullbergDepartment of Radiology and Biomedical Imaging, University of California, 185 Berry St., Suite 350, San Francisco, CA, 94143-0946, USA.
Elias H BotvinickDepartment of Radiology and Biomedical Imaging, University of California, 185 Berry St., Suite 350, San Francisco, CA, 94143-0946, USA.

Funding

DYNAMIC CARDIAC SPECT IMAGINGR01HL050663 · NHLBI · UNIVERSITY OF UTAH · PI GULLBERG, GRANT T · 1995 to 2014
$7.0M
NHLBI NIH HHS R01 HL050663
6 · The paper itself

Abstract

backgroundRisk stratification and early detection of cardiac allograft vasculopathy (CAV) is essential in orthotopic heart transplantation (OHT) patients. This study assesses the changes in myocardial blood flow (MBF) noninvasively in OHT patients using quantitative cardiac PET with regadenoson.

methodsTwelve patients (Group 1) (8 males, 4 females, mean age 55 ± 7 years) with no history of post OHT myocardial ischemia were enrolled 5.4 ± 2.0 years after OHT. Fifteen patients (Group 2) (9 males, 6 females, mean age 71 ± 9 years) with intermediate pretest probability but not documented evidence for coronary artery disease (CAD) were also included to serve as control. Global and regional MBFs were assessed using dynamic

resultsMean regadenoson-induced rate-pressure products were similar in both groups, while there was an increase in resting rate-pressure product in Group 1 patients. Both mean and median values of resting MBF were higher in Group 1 than Group 2 patients (1.33 ± 0.31 and 1.01 ± 0.21 mL/min/g for Groups 1 and 2, respectively, P < .001), while mean hyperemic MBF values were similar in both Groups (2.68 ± 0.84 and 2.64 ± 0.94 mL/min/g, P = NS) but median hyperemic MBF values were lower in Group 1 than Group 2 patients (2.0 vs. 2.60 mL/min/g, P = .018). Both mean and median CFR values demonstrated a significant reduction for Group 1 compared to Group 2 patients (2.07 ± 0.74 vs 2.63 ± 0.48, P = .025).

conclusionsThis study suggests that the MBF in OHT patients may be abnormal at resting state with diminished CFR. This hints that the epicardial and microvascular coronary subsystem may be exacerbated after OHT leading to the gradual progression of CAV.

Indexed as

Coronary CirculationAdultAgedAged, 80 and overFemaleHeart TransplantationHumansMaleMiddle AgedPositron-Emission TomographyPurinesPyrazolesTransplantation, HomologousVascular DiseasesPurinesPyrazolesregadenosoncardiac allograft vasculopathycoronary flow reserveDynamic PETorthotopic heart transplantregadenoson

Identifiers

PMID28138813
PMCPMC5534390

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.