ArticleScience advances2017
Concurrence of extracellular vesicle enrichment and metabolic switch visualized label-free in the tumor microenvironment.
Article in Science advances, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- From Label-Free Multiphoton Imaging to Pathological Reports: A Vision-Language Breast Cancer Margin Pathological Diagnosis System.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Towards next-generation diagnostic pathology: AI-empowered label-free multiphoton microscopy.Light, science & applications · 2024Review
- Large field-of-view metabolic profiling of murine brain tissue following morphine incubation using label-free multiphoton microscopy.Journal of neuroscience methods · 2024Article
- Label-free nonlinear optical signatures of extracellular vesicles in liquid and tissue biopsies of human breast cancer.Scientific reports · 2024Article
- Noninvasive Nonlinear Optical Computational Histology.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Label-free biomedical optical imaging.Nature photonics · 2023Article
- Label-free approaches for extracellular vesicle detection.iScience · 2023Review
- In vivo label-free optical signatures of chemotherapy response in human pancreatic ductal adenocarcinoma patient-derived xenografts.Communications biology · 2023Article
- Label-Free Optical Metabolic Imaging in Cells and Tissues.Annual review of biomedical engineering · 2023Review
- Extracellular vesicle-matrix interactions.Nature reviews. Materials · 2023Article
- Weakly supervised identification of microscopic human breast cancer-related optical signatures from normal-appearing breast tissue.Biomedical optics express · 2023Article
- Nonlinear optical imaging by detection with optical parametric amplification (invited paper).Journal of innovative optical health sciences · 2023Article
- Label-free multimodal nonlinear optical imaging of needle biopsy cores for intraoperative cancer diagnosis.Journal of biomedical optics · 2022Article
- Super-Multiplex Nonlinear Optical Imaging Unscrambles the Statistical Complexity of Cancer Subtypes and Tumor Microenvironment.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Label-free optical redox ratio from urinary extracellular vesicles as a screening biomarker for bladder cancer.American journal of cancer research · 2022Article
- Deep-skin multiphoton microscopy of lymphatic vessels excited at the 1700-nm window in vivo.Biomedical optics express · 2021Article
- Label-Free Deep Profiling of the Tumor Microenvironment.Cancer research · 2021Article
- Multi-modal nonlinear optical and thermal imaging platform for label-free characterization of biological tissue.Scientific reports · 2021Article
- Label-Free Multimodal Multiphoton Intravital Imaging.Advances in experimental medicine and biology · 2021Article
- Real-time three-dimensional histology-like imaging by label-free nonlinear optical microscopy.Quantitative imaging in medicine and surgery · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Understanding the role of the tumor microenvironment in carcinogenesis has reshaped cancer research. Events at both microscopic (molecular) and macroscopic (tissue) scales have been identified in engineered tumor microenvironments involving in vitro cultures, live tissue xenografts, and transgenic animals. However, these events have not been comprehensively observed under unperturbed (authentic) conditions free of exogenous labeling or genetic modification. The lack of a suitable imaging methodology has largely limited our understanding of the complex interrelations and possible causal links involved in carcinogenesis and metastasis within the tumor microenvironment. Using multicontrast nonlinear imaging, we visualize endogenous substances in rat and human mammary tumors through their intrinsic nonlinear optical properties, and simultaneously observe angiogenesis, extracellular matrix reorganization, and non-native cell recruitment. We find that all these macroscopic events in the tumor microenvironment require concurrent enrichment of specific extracellular vesicles and a metabolic switch toward biosynthesis. This concurrence at the microscopic scale provides not only new insights into carcinogenesis and metastasis but also a potentially new strategy for cancer diagnosis, surgery, and therapeutics.
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