ArticleScience advances2016
KDM5 lysine demethylases are involved in maintenance of 3'UTR length.
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Article in Science advances, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
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Who cites it
23 citing papers in PubMed, 35 citations in OpenAlex.
- KDM5A methylation modulates its genomic demethylase and transcriptional actions.The Journal of biological chemistry · 2026Article
- Transcription factor 19 modulates fatty acid elongation and unfolded protein response to attenuate palmitic acid-induced hepatic dysfunction.Nature communications · 2026Article
- Emerging role ofFrontiers in molecular neuroscience · 2026Article
- Histone lysine demethylases in breast cancer: molecular mechanisms, biological functions, and therapeutic intervention.Molecular cancer · 2025Review
- Canonical and Non-Canonical Functions of Histone H3K4 Methylation Modifiers in Cancer.Cancer science · 2025Review
- IGF2BP2 binding to CPSF6 facilitates m6A-mediated alternative polyadenylation of PUM2 and promotes malignant progression in ovarian cancer.Clinical and translational medicine · 2025Article
- Design and characterization of G-quadruplex RNA aptamers reveal RNA-binding by KDM5 lysine demethylases.Computational and structural biotechnology journal · 2025Article
- Delineating yeast cleavage and polyadenylation signals using deep learning.Genome research · 2024Article
- Histone demethylase JARID1C/KDM5C regulates Th17 cells by increasing IL-6 expression in diabetic plasmacytoid dendritic cells.JCI insight · 2024Article
- A CPF-like phosphatase module links transcription termination to chromatin silencing.Molecular cell · 2024Article
- KDM5 family as therapeutic targets in breast cancer: Pathogenesis and therapeutic opportunities and challenges.Molecular cancer · 2024Review
- Bladder Cancer, Loss of Y Chromosome, and New Opportunities for Immunotherapy.Advances in therapy · 2024Article
- KDM5 Lysine Demethylases in Pathogenesis, from Basic Science Discovery to the Clinic.Advances in experimental medicine and biology · 2023Article
- Phosphorylation of Jhd2 by the Ras-cAMP-PKA(Tpk2) pathway regulates histone modifications and autophagy.Nature communications · 2022Article
- Ready, SET, Go: Post-translational regulation of the histone lysine methylation network in budding yeast.The Journal of biological chemistry · 2021Review
- The emerging role of KDM5A in human cancer.Journal of hematology & oncology · 2021Review
- Review
- Regulation of alternative polyadenylation in the yeast Saccharomyces cerevisiae by histone H3K4 and H3K36 methyltransferases.Nucleic acids research · 2020Article
- RNA polymerase II (RNAP II)-associated factors are recruited to tRNA loci, revealing that RNAP II- and RNAP III-mediated transcriptions overlap in yeast.The Journal of biological chemistry · 2019Article
- LSH interacts with and stabilizes GINS4 transcript that promotes tumourigenesis in non-small cell lung cancer.Journal of experimental & clinical cancer research : CR · 2019Article
Corrections and comments
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Authors and funding
17 authors at 5 institutions in 1 country.
Lauren P BlairDepartment of Pathology, Yale School of Medicine, New Haven, CT 06520, USA.
Zongzhi LiuDepartment of Pathology, Yale School of Medicine, New Haven, CT 06520, USA.
Ramon Lorenzo D LabitiganDepartment of Pathology, Yale School of Medicine, New Haven, CT 06520, USA.
Lizhen WuDepartment of Pathology, Yale School of Medicine, New Haven, CT 06520, USA.ORCID 0000-0002-0452-2602
Dinghai ZhengDepartment of Microbiology, Biochemistry and Molecular Genetics, Rutgers New Jersey Medical School, Newark, NJ 07103, USA.
Zheng XiaDivision of Biostatistics, Dan L Duncan Comprehensive Cancer Center and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0003-3364-8324
Erica L PearsonDepartment of Developmental, Molecular, and Chemical Biology, Tufts University School of Medicine, Boston, MA 02111, USA.
Fathima I NazeerDepartment of Developmental, Molecular, and Chemical Biology, Tufts University School of Medicine, Boston, MA 02111, USA.
Jian CaoDepartment of Pathology, Yale School of Medicine, New Haven, CT 06520, USA.
Sabine M LangDepartment of Pathology, Yale School of Medicine, New Haven, CT 06520, USA.ORCID 0000-0002-6486-5287
Rachel J RinesDepartment of Pathology, Yale School of Medicine, New Haven, CT 06520, USA.ORCID 0000-0002-5700-8885
Samuel G MackintoshDepartment of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR 72032, USA.
Claire L MooreDepartment of Developmental, Molecular, and Chemical Biology, Tufts University School of Medicine, Boston, MA 02111, USA.
Wei LiDivision of Biostatistics, Dan L Duncan Comprehensive Cancer Center and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
Bin TianDepartment of Microbiology, Biochemistry and Molecular Genetics, Rutgers New Jersey Medical School, Newark, NJ 07103, USA.
Alan J TackettDepartment of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR 72032, USA.
Qin YanDepartment of Pathology, Yale School of Medicine, New Haven, CT 06520, USA.ORCID 0000-0003-4077-453X
Yale University · USTufts University · USBaylor College of Medicine · USRutgers, The State University of New Jersey · USUniversity of Arkansas for Medical Sciences · US
Funding
Understanding Hesitant AdoptersP20GM103429 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI Lawrence E Cornett, JERRY WARE · 2012 to 2026
$60.9MStudy of the Cell-specific Inflammasome Responses During Defense Against Gram-negative BacteriaP20GM103625 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI SMELTZER, MARK S · 2012 to 2021
$21.5MArkansas Center for Clinical and Translational ResearchUL1TR000039 · NCATS · UNIV OF ARKANSAS FOR MED SCIS · PI BECK, CORNELIA MARIE, JAMES, LAURA P · 2012 to 2014
$10.0MRegulation of Alternative Cleavage and PolyadenylationR01GM084089 · NIGMS · WISTAR INSTITUTE · PI TIAN, BIN · 2008 to 2023
$6.7MCenter for Protein Structure and FunctionP30GM103450 · NIGMS · UNIVERSITY OF ARKANSAS AT FAYETTEVILLE · PI MILLETT, FRANCIS S · 2012 to 2014
$3.2MComputational and Experimental Modeling of Epigenetic DNA MethylationR01HG007538 · NHGRI · UNIVERSITY OF CALIFORNIA-IRVINE · PI LI, WEI · 2014 to 2018
$1.9MUsing ChAP-MS to Study Macromolecular Chromatin Composition during TranscriptionR01GM106024 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI TACKETT, ALAN, TAVERNA, SEAN D. · 2013 to 2016
$1.2MDevelopment of MassSQUIRM to Quantitatively Measure Lysine MethylationR33CA173264 · NCI · UNIV OF ARKANSAS FOR MED SCIS · PI TACKETT, ALAN · 2013 to 2015
$430kIDENTIFYING EPIGENETIC CHANGES CRITICAL FOR TRASTUZUMAB RESISTANCER21CA187862 · NCI · YALE UNIVERSITY · PI YAN, QIN · 2015 to 2016
$398kTARGETING EPIGENETIC REGULATORS TO SUPPRESS BREAST CANCER METASTASISR21CA191548 · NCI · YALE UNIVERSITY · PI YAN, QIN · 2015 to 2016
$398kNCATS NIH HHS UL1 TR000039NCI NIH HHS R21 CA187862NCI NIH HHS R21 CA191548NCI NIH HHS R33 CA173264NHGRI NIH HHS R01 HG007538NIGMS NIH HHS P20 GM103429NIGMS NIH HHS P20 GM103625NIGMS NIH HHS P30 GM103450NIGMS NIH HHS R01 GM084089NIGMS NIH HHS R01 GM106024
Abstract
The complexity by which cells regulate gene and protein expression is multifaceted and intricate. Regulation of 3' untranslated region (UTR) processing of mRNA has been shown to play a critical role in development and disease. However, the process by which cells select alternative mRNA forms is not well understood. We discovered that the
Indexed as
3' Untranslated RegionsBreast NeoplasmsCyclin D1DEAD-box RNA HelicasesFemaleHumansJumonji Domain-Containing Histone DemethylasesMCF-7 CellsNeoplasm ProteinsNuclear ProteinsRepressor ProteinsRetinoblastoma-Binding Protein 2Ribonuclease IIISaccharomyces cerevisiaeSaccharomyces cerevisiae Proteins3' Untranslated RegionsCCND1 protein, humanCyclin D1DEAD-box RNA HelicasesDICER1 protein, humanJHD2 protein, S cerevisiaeJumonji Domain-Containing Histone DemethylasesKDM5A protein, humanKDM5B protein, humanNeoplasm ProteinsNuclear ProteinsRepressor ProteinsRetinoblastoma-Binding Protein 2Ribonuclease IIISaccharomyces cerevisiae Proteinsalternative polyadenylationCCND1DICER1JARID1Jhd2KDM5KDM5AKDM5BKDM5CLysine demethylase 5
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