ArticleClinical psychological science : a journal of the Association for Psychological Science2017
Impact of Panic on Psychophysiological and Neural Reactivity to Unpredictable Threat in Depression and Anxiety.
Article in Clinical psychological science : a journal of the Association for Psychological Science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neurocircuitry and Neuroanatomy in Panic Disorder: A Systematic Review.Alpha psychiatry · 2025Pooled it
- Sleep quality impacts the link between reactivity to uncertain threat and anxiety and alcohol use in youth.Psychophysiology · 2024Article
- In Search of the Behavioral and Neural Basis for Differentiating Fear and Anxiety.Biological psychiatry global open science · 2024Article
- Transdiagnostic Fear and Anxiety: Prospective Prediction Using the No-Threat, Predictable Threat, and Unpredictable Threat Task.Biological psychiatry global open science · 2023Article
- Don't worry, it won't be fine. Contributions of worry and anxious arousal to startle responses and event-related potentials in threat anticipation.Cognitive, affective & behavioral neuroscience · 2023Article
- Are Fear and Anxiety Truly Distinct?Biological psychiatry global open science · 2022Review
- Association between startle reactivity to uncertain threats and structural brain volume.Psychophysiology · 2022Article
- Shared and unique neural circuitry underlying temporally unpredictable threat and reward processing.Social cognitive and affective neuroscience · 2021Article
- Gender differences in anxiety: The mediating role of sensitivity to unpredictable threat.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2020Article
- The Relation Between Posttraumatic Stress Symptom Severity and Startle Potentiation to Predictable and Unpredictable Threat.The Journal of nervous and mental disease · 2020Article
- Neural correlates of predictable and unpredictable threat in internalizing psychopathology.Neuroscience letters · 2019Article
- Brain activation during disorder-related script-driven imagery in panic disorder: a pilot study.Scientific reports · 2019Article
- The central extended amygdala in fear and anxiety: Closing the gap between mechanistic and neuroimaging research.Neuroscience letters · 2019Review
- Impact of posttraumatic stress symptom dimensions on psychophysiological reactivity to threat and reward.Journal of psychiatric research · 2017Article
- Impact of anxiety symptoms and problematic alcohol use on error-related brain activity.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2017Article
- Association between neural reactivity and startle reactivity to uncertain threat in two independent samples.Psychophysiology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Exaggerated anxious responding to unpredictable threat (U-threat) is a core feature of panic disorder (PD). However, it is unknown whether this abnormality is specific to the diagnosis of PD or would manifest along a continuum of panic symptomatology (PS). Additionally, little is known about the neural processes underlying this abnormality among those high in PS. Finally, no studies have tested whether startle potentiation and limbic neural reactivity - commonly used indices of U-threat responsivity - are associated and therefore reflect common abnormalities. These questions were investigated in 42 adults with a range of PS. U-threat responding was measured twice during threat-of-shock - once with startle and once with functional magnetic resonance imaging (fMRI). As hypothesized, PS positively predicted startle potentiation and dACC reactivity to U-threat. Startle potentiation and dACC activation to U-threat were positively associated. These results suggest a biobehavioral profile of aberrant responding to U-threat associated with PS.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.