ReviewWorld journal of gastrointestinal surgery2017
Perforated peptic ulcer - an update.
Review in World journal of gastrointestinal surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 116 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparison Between Open vs Laparoscopic Repair of Perforated Peptic Ulcer
Suture-closure omentopexy versus omentopexy alone in repair of perforated peptic ulcer
Who cites it
116 citing papers in PubMed, 5 syntheses or guidelines pooled it, 327 citations in OpenAlex.
- Perforated peptic ulcers in children: a systematic review.BMC pediatrics · 2025Pooled it
- Laparoscopic versus open repair for peptic ulcer perforation: a systematic review, meta-analysis and trial sequential analysis of randomised controlled trials. Time to conclude!Annals of the Royal College of Surgeons of England · 2025Pooled it
- Unfavorable outcomes and their predictors in patients treated for perforated peptic ulcer disease in Ethiopia: systematic review and meta-analysis.BMC gastroenterology · 2025Pooled it
- Alternative treatments to treat perforated peptic ulcer: a systematic review and network meta-analysis of randomized controlled trials.World journal of emergency surgery : WJES · 2025Pooled it
- Perforated and bleeding peptic ulcer: WSES guidelines.World journal of emergency surgery : WJES · 2020Guideline
- Enhanced recovery after surgery versus conventional approach in peptic perforation- a Randomized Controlled Trial- "ERASE trial".World journal of emergency surgery : WJES · 2025Trial
- Combined endoscopic and radiologic intervention for management of acute perforated peptic ulcer: a randomized controlled trial.World journal of emergency surgery : WJES · 2022Trial
- Duodenal perforation masquerading as an intra-abdominal abscess: successful management with pedicled falciformopexy.Journal of surgical case reports · 2026Article
- Perforated gastric schwannoma treated with laparoscopic wedge gastrectomy: a rare case report.International journal of surgery case reports · 2026Article
- Diagnostic utility of a CT upper gastrointestinal protocol for the detection of gastroduodenal leaks.Abdominal radiology (New York) · 2026Article
- Outcomes and Predictors of Mortality in Perforated Versus Non-Perforated Peptic Ulcer Disease: A U.S. Nationwide Propensity-Matched Analysis, 2016-2021.Journal of clinical medicine · 2026Article
- Early Risk Stratification and Mortality Prediction in Gastrointestinal Perforation: A Retrospective Cohort Study for Personalized Surgical Decision Making.Journal of personalized medicine · 2026Article
- Peptic ulcer disease in hospitalized patients: a comprehensive risk factor analysis using a validated checklist.BMC gastroenterology · 2026Article
- Evidence-based, cost-effective management of perforated peptic ulcer disease: An algorithm of the Journal of Trauma and Acute Care Surgery Emergency General Surgery Algorithms Working Group.The journal of trauma and acute care surgery · 2026Article
- Pedicled falciformopexy as an alternative surgical technique in peptic ulcer perforation: a case report and review of the literature.International journal of surgery case reports · 2026Article
- Feasibility and outcomes of laparoscopic management in perforation peritonitis: A prospective cohort study with propensity score matching.Journal of minimal access surgery · 2026Article
- Perforated peptic ulcer disease in a resource-limited setting: a retrospective analysis of a South African cohort.BMC gastroenterology · 2026Article
- Predictors of postoperative complications after surgery for perforated peptic ulcer: a prospective study from a tertiary center of Nepal.Annals of medicine and surgery (2012) · 2026Article
- A cross-sectional study of demographic profile and incidence ofInternational journal of surgery open · 2025Article
- Rare case of thrombolysis for ischemic stroke with a concurrent perforated duodenal ulcer.Journal of surgical case reports · 2025Article
56 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Peptic ulcer disease (PUD) affects 4 million people worldwide annually. The incidence of PUD has been estimated at around 1.5% to 3%. Perforated peptic ulcer (PPU) is a serious complication of PUD and patients with PPU often present with acute abdomen that carries high risk for morbidity and mortality. The lifetime prevalence of perforation in patients with PUD is about 5%. PPU carries a mortality ranging from 1.3% to 20%. Thirty-day mortality rate reaching 20% and 90-d mortality rate of up to 30% have been reported. In this review we have summarized the current evidence on PPU to update readers. This literature review includes the most updated information such as common causes, clinical features, diagnostic methods, non-operative and operative management, post-operative complications and different scoring systems of PPU. With the advancement of medical technology, PUD can now be treated with medications instead of elective surgery. The classic triad of sudden onset of abdominal pain, tachycardia and abdominal rigidity is the hallmark of PPU. Erect chest radiograph may miss 15% of cases with air under the diaphragm in patients with bowel perforation. Early diagnosis, prompt resuscitation and urgent surgical intervention are essential to improve outcomes. Exploratory laparotomy and omental patch repair remains the gold standard. Laparoscopic surgery should be considered when expertise is available. Gastrectomy is recommended in patients with large or malignant ulcer.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.