ArticleGenes & nutrition2017
Effect of high carbohydrate diet on elongase and desaturase activity and accompanying gene expression in rat's liver.
Article in Genes & nutrition, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- Hyperglycemia and Alteration in Sphingolipids Are Early Mediators of Diabetic Kidney Disease: Role of Elongase 1.American journal of nephrology · 2026Article
- Age-related alterations in fatty acid metabolism: a clinical study of erythrocyte and plasma profiles in a population from Brandenburg, Germany.Frontiers in aging · 2026Article
- Fatty Acid Profile and Desaturase Activity in Obesity: Roles, Mechanisms, and Clinical Relevance.Metabolites · 2025Review
- Influence of a Combination of Glycerol Polyethylene Glycol Ricinoleate and Bi-Distilled Oleic Acid in Powder Form on Growth Performance, Nutrient Digestibility, Excreta Nitrogen and Liver Fatty Acid Profile of Broilers Fed Reduced-Energy Diets.Animals : an open access journal from MDPI · 2025Article
- Selection scan in Native Americans of Mexico identifiesHeliyon · 2024Article
- Fatty Acids and Their Lipogenic Enzymes in Anorexia Nervosa Clinical Subtypes.International journal of molecular sciences · 2024Article
- Stearoyl CoA Desaturase-1 Silencing in Glioblastoma Cells: Phospholipid Remodeling and Cytotoxicity Enhanced upon Autophagy Inhibition.International journal of molecular sciences · 2022Article
- The association between dietary glycemic index and cardio-metabolic risk factors in obese individuals.BMC nutrition · 2022Article
- The Obscure Effect ofInternational journal of molecular sciences · 2021Article
- Diet Regulation of Long-Chain PUFA Synthesis: Role of Macronutrients, Micronutrients, and Polyphenols on Δ-5/Δ-6 Desaturases and Elongases 2/5.Advances in nutrition (Bethesda, Md.) · 2021Review
- Exogenous Fatty Acids Modulate ER Lipid Composition and Metabolism in Breast Cancer Cells.Cells · 2021Article
- Article
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- Expression ofBiomolecules · 2020Article
- Low protein diet and methyl-donor supplements modify testicular physiology in mice.Reproduction (Cambridge, England) · 2020Article
- A high-carbohydrate diet induces greater inflammation than a high-fat diet in mouse skeletal muscle.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2020Article
- Food-Intake Normalization of Dysregulated Fatty Acids in Women with Anorexia Nervosa.Nutrients · 2019Article
- Nonylphenol aggravates non-alcoholic fatty liver disease in high sucrose-high fat diet-treated rats.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHepatic fatty acids (FAs) are modified through different metabolic pathways including elongation and desaturation. These processes are catalyzed by elongases and desaturases, respectively. Glucose, by transcription factors, regulates these processes. The aim of the study was to evaluate the influence of high carbohydrate diet (68%) on the expression of elongase (Elovl-2, Elovl-5, and Elovl-6) and desaturase (∆5D, ∆6D, Scd 1, Scd 2) genes and the activity of the enzymes. The changes in serum lipid profile (triglycerides (TG), total cholesterol (TC), HDL cholesterol) and glucose concentration were measured. Male Wistar rats were randomized into two study groups: animals fed with high carbohydrate diet (
resultsThe mean values of transcript expression of all examined elongases and desaturases in liver HiCHO rats were higher as compared to ST. Higher expression did not always correspond to higher activity (as index). More monounsaturated FAs (MUFAs) were detected in the liver of HiCHO rats as compared to ST. Serum TG level was higher in the HiCHO than in ST.
conclusionsThese studies support the notion that the regulation of both Elovl and desaturase expression may play an important role in managing hepatic lipid composition in response to changes in dietary status.
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