Evidence map›Paper›PMID 28138303›Full record

ArticleInternational journal of medical sciences2017

Amino Acid Profiles of Serum and Urine in Search for Prostate Cancer Biomarkers: a Pilot Study.

Paweł Dereziński, Agnieszka Klupczynska, Wojciech Sawicki, Jerzy A Pałka, Zenon J Kokot

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of medical sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05672758 (The Effect of Long-lasting Adaptation to Intensive Speed-power and Endurance Training on Plasma Free Amino Acids Concentration at Rest, During Graded Exercise and Post-exercise Recovery), which is not on this map. Cited by 58 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 3 pooled it
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05672758 unknown statusnot on this mapstarted 2018, after this paper: background citation

The Effect of Long-lasting Adaptation to Intensive Speed-power and Endurance Training on Plasma Free Amino Acids Concentration at Rest, During Graded Exercise and Post-exercise Recovery

TypeobservationalSponsorPoznan University of Physical EducationRan2018 to 2023Enrolled58ConditionsHealthy Athletes Aged 18-35 YearsArmsSprint training, Endurance training, Recreational Training
3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 3 syntheses or guidelines pooled it, 114 citations in OpenAlex.

  1. Pooled it
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  5. Review
  6. Review
  7. Serum metabolic patterns reveal the diagnostic and prognostic role of alanine abnormality in ocular adnexal lymphoma.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  8. Article
  9. Cellular Signaling of Amino Acid Metabolism in Prostate Cancer.International journal of molecular sciences · 2025
    Review
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  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Paweł DerezińskiDepartment of Inorganic and Analytical Chemistry, Poznan University of Medical Sciences, 6 Grunwaldzka Street, 60-780 Poznań, Poland.
Agnieszka KlupczynskaDepartment of Inorganic and Analytical Chemistry, Poznan University of Medical Sciences, 6 Grunwaldzka Street, 60-780 Poznań, Poland.
Wojciech SawickiWard of Urology, The Holy Family Hospital, 18 Jarochowskiego Street, 60-235 Poznań, Poland.
Jerzy A PałkaDepartment of Medicinal Chemistry, Medical University of Bialystok, 2d Mickiewicza Street, 15-222 Białystok, Poland.
Zenon J KokotDepartment of Inorganic and Analytical Chemistry, Poznan University of Medical Sciences, 6 Grunwaldzka Street, 60-780 Poznań, Poland.
Poznan University of Medical Sciences · PLHoly Family Hospital · INMedical University of Białystok · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is a great interest in searching for diagnostic biomarkers in prostate cancer patients. The aim of the pilot study was to evaluate free amino acid profiles in their serum and urine. The presented paper shows the first comprehensive analysis of a wide panel of amino acids in two different physiological fluids obtained from the same groups of prostate cancer patients (n = 49) and healthy men (n = 40). The potential of free amino acids, both proteinogenic and non-proteinogenic, as prostate cancer biomarkers and their utility in classification of study participants have been assessed. Several metabolites, which deserve special attention in the further metabolomic investigations on searching for prostate cancer markers, were indicated. Moreover, free amino acid profiles enabled to classify samples to one of the studied groups with high sensitivity and specificity. The presented research provides a strong evidence that ethanolamine, arginine and branched-chain amino acids metabolic pathways can be a valuable source of markers for prostate cancer. The altered concentrations of the above-mentioned metabolites suggest their role in pathogenesis of prostate cancer and they should be further evaluated as clinically useful markers of prostate cancer.

Indexed as

AdultAgedAged, 80 and overAmino AcidsBiomarkers, TumorCase-Control StudiesChromatography, LiquidHumansMaleMiddle AgedMultivariate AnalysisPilot ProjectsProstatic NeoplasmsSpectrometry, Mass, Electrospray IonizationTandem Mass SpectrometryAmino AcidsBiomarkers, Tumoramino acidsmetabolomicsprostate cancerserumurine.

Identifiers

PMID28138303
PMCPMC5278653
OpenAlexW2566760664

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.