Evidence map›Paper›PMID 28138240›Full record

ArticleInternational journal of nanomedicine2017

Plant-derived pectin nanocoatings to prevent inflammatory cellular response of osteoblasts following

Anna Meresta, Justyna Folkert, Timo Gaber, Korneliusz Miksch, Frank Buttgereit, Jacqueline Detert, Nicole Pischon, Katarzyna Gurzawska

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of nanomedicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 4 countries.

Anna MerestaEnvironmental Biotechnology Department, Faculty of Power and Environmental, Silesian University of Technology, Gliwice, Poland.
Justyna FolkertEnvironmental Biotechnology Department, Faculty of Power and Environmental, Silesian University of Technology, Gliwice, Poland.
Timo GaberDepartment of Rheumatology and Clinical Immunology.
Korneliusz MikschEnvironmental Biotechnology Department, Faculty of Power and Environmental, Silesian University of Technology, Gliwice, Poland.
Frank ButtgereitDepartment of Rheumatology and Clinical Immunology.
Jacqueline DetertDepartment of Rheumatology and Clinical Immunology.
Nicole PischonDepartment of Periodontology, Charité University Medicine, Berlin, Germany.
Katarzyna GurzawskaDepartment of Periodontology, Charité University Medicine, Berlin, Germany; Oral Surgery Department, The School of Dentistry, University of Birmingham, Birmingham, UK.
Center for Rheumatology · USSilesian University of Technology · PLCharité - Universitätsmedizin Berlin · DEUniversity of Birmingham · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBioengineered plant-derived Rhamnogalacturonan-Is (RG-Is) from pectins are potential candidates for surface nanocoating of medical devices. It has recently been reported that RG-I nanocoatings may prevent bacterial infection and improve the biocompatibility of implants. The aim of the study was to evaluate in vitro impact of bioengineered RG-I nanocoatings on osteogenic capacity and proinflammatory cytokine response of murine osteoblasts following

methodsMurine MC3T3-E1 osteoblasts and isolated primary calvarial osteoblasts from C57BL/6J (B6J osteoblasts) mice were infected with

resultsFollowing

conclusionOur data clearly showed that pectin RG-Is nanocoating with high content of galactan (PA) reduces the osteoblastic response to

Indexed as

AnimalsCell ProliferationCells, CulturedCell ShapeCoated Materials, BiocompatibleGene Expression RegulationInflammationMice, Inbred C57BLNanoparticlesOsteoblastsPectinsPorphyromonas gingivalisReal-Time Polymerase Chain ReactionSolanum tuberosumCoated Materials, BiocompatiblePectinsinflammationnanocoatingsosteoblastsPorphyromonas gingivalisRhamnogalacturonan-I

Identifiers

PMID28138240
PMCPMC5238760
OpenAlexW2578890799

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.