ArticlePatient preference and adherence2017
Health-related quality of life in patients with chronic hepatitis B during antiviral treatment and off-treatment.
Article in Patient preference and adherence, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 55 citations in OpenAlex.
- Health-related quality of life improves after entecavir treatment in patients with compensated HBV cirrhosis.Hepatology international · 2021Trial
- Health-related quality of life in adults with hepatitis B in sub-Saharan Africa: the added burden of HIV co-infection.BMC infectious diseases · 2026Observational
- Development of a hypersensitive digital ELISA system for hepatitis B core antigen.Analytical and bioanalytical chemistry · 2026Article
- HEALTH-RELATED QUALITY OF LIFE IN CHRONIC LIVER DISEASE: CLINICAL BURDEN, DETERMINANTS, AND IMPLICATIONS FOR PATIENT-CENTERED CARE.Arquivos de gastroenterologia · 2026Review
- The interprofessional nurse-physician model in comprehensive management of chronic hepatitis B: An updated review.Journal of virus eradication · 2025Review
- Quality of life in patients with HBV infection: A systematic review and meta-analysis.JHEP reports : innovation in hepatology · 2025Article
- Trajectory and predictors of adherence to Nucleos(t)ide analogues medication among patients with chronic hepatitis B.Heliyon · 2024Article
- Symptoms of Liver Disease During Tenofovir Therapy With or Without Peginterferon: Results from the Hepatitis B Research Network Immune Active Trial.Digestive diseases and sciences · 2023Article
- Health-related quality of life for adults living with hepatitis B in the United States: a qualitative assessment.Journal of patient-reported outcomes · 2021Article
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- Article
- Observational
- The Lived Experience of Chronic Hepatitis B: A Broader View of Its Impacts and Why We Need a Cure.Viruses · 2020Review
- Effects of Depression, Anxiety, Stigma, and Disclosure on Health-Related Quality of Life among Chronic Hepatitis B Patients in Dalian, China.The American journal of tropical medicine and hygiene · 2020Article
- Depression, Anxiety, Psychological Symptoms and Health-Related Quality of Life in People Living with HIV.Patient preference and adherence · 2020Article
- Comparison of clinical features and outcomes between HBV-related and non-B non-C hepatocellular carcinoma.Infectious agents and cancer · 2020Article
- The Impact of Virologic Parameters and Liver Fibrosis on Health-Related Quality of Life in Black African Patients with Chronic Hepatitis B: Results from a High Endemic Area.Clinical and experimental gastroenterology · 2020Article
- Development and initial validation of the chronic hepatitis B quality of life instrument (CHBQOL) among Chinese patients.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2019Article
- Association between abdominal obesity and liver steatosis and fibrosis among patients with chronic hepatitis B measured by Fibroscan.Experimental and therapeutic medicine · 2019Article
- Risk factors associated with hepatic osteopathy in HBV related cirrhosis measured by liver stiffness: An Observational study.Medicine · 2019Observational
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionHealth-related quality of life (HRQoL) has emerged as an important consideration in the care of patients with chronic hepatitis B (CHB). However, whether benefits from the improved HRQoL that occurs after antiviral treatment or drug discontinuation outweigh the risks of viral relapse is an unanswered question. The aim of this study was to evaluate the HRQoL among patients with CHB during antiviral treatment and withdrawal of treatment. PATIENTS AND
methodsThere were 102 patients who met the enrollment criteria with 54 patients in the treatment group and 48 patients in the discontinuation group. Sociodemographic information was collected. The 36-Item Short-Form Health Survey (SF-36), European Quality of Life-5 Dimensions, and Beck Depression Inventory (BDI) were adopted to evaluate life quality and mental health.
resultsIn the treatment group, SF-36 showed that the physical functions were significantly increased. In the discontination group, the psychological functions showed improvement. A multivariate regression analysis indicated that baseline SF-36 score was a predictor for improvement in HRQoL (odds ratio =1.17,
conclusionAntiviral treatment benefits the physical health of the patients with CHB, while conferring no obvious improvement in their psychological condition. Improved psychological interventions for patients with CHB, especially for those with lower baseline SF-36 scores and higher BDI scores, may improve their quality of life.
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