Evidence map›Paper›PMID 28138133›Full record

Trial reportInternational journal of obesity (2005)2017

Thyroid hormones and changes in body weight and metabolic parameters in response to weight loss diets: the POUNDS LOST trial.

G Liu, L Liang, G A Bray, L Qi, F B Hu, J Rood, F M Sacks, Q Sun

Abstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in International journal of obesity (2005), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 1 synthesis or guideline pooled it, 79 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

G LiuDepartment of Nutrition, Harvard TH Chan School of Public Health, Boston, MA, USA.
L LiangDepartment of Epidemiology and Department of Biostatistics, Harvard TH Chan School of Public Health, Boston, MA, USA.
G A BrayPennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA.
L QiDepartment of Nutrition, Harvard TH Chan School of Public Health, Boston, MA, USA.
F B HuDepartment of Nutrition, Harvard TH Chan School of Public Health, Boston, MA, USA.
J RoodPennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA.
F M SacksDepartment of Nutrition, Harvard TH Chan School of Public Health, Boston, MA, USA.
Q SunDepartment of Nutrition, Harvard TH Chan School of Public Health, Boston, MA, USA.
Brigham and Women's Hospital · USHarvard University · USLouisiana State University · USShanghai Institutes for Biological Sciences · CNTulane University · US

Funding

Zoledronic Acid in Treatment of Osteoporosis in PostmenoM01RR002635 · NCRR · BRIGHAM AND WOMEN'S HOSPITAL · PI WILLIAMS, GORDON H · 1985 to 2008
$48.4M
Dietary Macronutrients and Weight LossU01HL073286 · NHLBI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI SACKS, FRANK M · 2003 to 2008
$7.6M
Environmental Obesogens and Weight Change in the POUNDS LOST TrialR01ES022981 · NIEHS · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI SUN, QI · 2014 to 2024
$4.7M
Weight-Loss Diet Intervention on Cardiometabolic Factors of Gut MicrobiotaR01DK100383 · NIDDK · TULANE UNIVERSITY OF LOUISIANA · PI QI, LU · 2014 to 2024
$4.2M
Pollutant-related diabetes in the Nurses' Health Study IIR01ES021372 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI GRANDJEAN, PHILIPPE ADAM, SUN, QI · 2013 to 2017
$2.9M
Novel Adipokines and Coronary Heart Disease in U.S. Men and Women with DiabetesR00HL098459 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SUN, QI · 2012 to 2014
$729k
NCRR NIH HHS M01 RR002635NHLBI NIH HHS R00 HL098459NHLBI NIH HHS U01 HL073286NIDDK NIH HHS R01 DK100383NIEHS NIH HHS R01 ES021372NIEHS NIH HHS R01 ES022981
6 · The paper itself

Abstract

backgroundThe role of thyroid hormones in diet-induced weight loss and subsequent weight regain is largely unknown.

objectivesTo examine the associations between thyroid hormones and changes in body weight and resting metabolic rate (RMR) in a diet-induced weight loss setting. SUBJECTS/

methodsData analysis was conducted among 569 overweight and obese participants aged 30-70 years with normal thyroid function participating in the 2-year Prevention of Obesity Using Novel Dietary Strategies (POUNDS) LOST randomized clinical trial. Changes in body weight and RMR were assessed during the 2-year intervention. Thyroid hormones (free triiodothyronine (T3), free thyroxine (T4), total T3, total T4 and thyroid-stimulating hormone (TSH)), anthropometric measurements and biochemical parameters were assessed at baseline, 6 months and 24 months.

resultsParticipants lost an average of 6.6 kg of body weight during the first 6 months and subsequently regained an average of 2.7 kg of body weight over the remaining period from 6 to 24 months. Baseline free T3 and total T3 were positively associated, whereas free T4 was inversely associated, with baseline body weight, body mass index and RMR. Total T4 and TSH were not associated with these parameters. Higher baseline free T3 and free T4 levels were significantly associated with a greater weight loss during the first 6 months (P<0.05) after multivariate adjustments including dietary intervention groups and baseline body weight. Comparing extreme tertiles, the multivariate-adjusted weight loss±s.e. was -3.87±0.9 vs -5.39±0.9 kg for free T3 (P

conclusionsIn this diet-induced weight loss setting, higher baseline free T3 and free T4 predicted more weight loss, but not weight regain among overweight and obese adults with normal thyroid function. These findings reveal a novel role of thyroid hormones in body weight regulation and may help identify individuals more responsive to weight loss diets.

Indexed as

Diet, ReducingAdultAgedBody Mass IndexBody Weight MaintenanceCaloric RestrictionEnergy MetabolismFemaleHumansLeptinMaleMiddle AgedOverweightThyroid HormonesWaist CircumferenceWeight LossLeptinThyroid Hormones

Identifiers

PMID28138133
PMCPMC5461198
OpenAlexW2585988790

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.