ReviewNature reviews. Nephrology2017
Physical inactivity: a risk factor and target for intervention in renal care.
Review in Nature reviews. Nephrology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 138 papers, 12 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
138 citing papers in PubMed, 12 syntheses or guidelines pooled it, 273 citations in OpenAlex.
- Physical activity interventions in adult kidney transplant recipients: an updated systematic review and meta-analysis of randomized controlled trials.Renal failure · 2025Pooled it
- Prescribing Physical Activity and Exercise for People with CKD: A Practical Guide by the Global Renal Exercise Network.Clinical journal of the American Society of Nephrology : CJASN · 2025Guideline
- Therapeutic Potential of Ketogenic Interventions for Autosomal-Dominant Polycystic Kidney Disease: A Systematic Review.Nutrients · 2024Pooled it
- Objectively measured daily steps as an outcome in a clinical trial of chronic kidney disease: a systematic review.BMC nephrology · 2024Pooled it
- Handgrip strength and all-cause mortality in patients with chronic kidney disease: an updated systematic review and meta-analysis of cohort studies.International urology and nephrology · 2023Pooled it
- Interventions to increase physical activity level in patients with whole spectrum chronic kidney disease: a systematic review and meta-analysis.Renal failure · 2023Pooled it
- Pooled it
- A systematic review of trials investigating the efficacy of exercise training for functional capacity and quality of life in chronic kidney disease patients.International urology and nephrology · 2022Pooled it
- Daily Step Counts in Patients With Chronic Kidney Disease: A Systematic Review and Meta-Analysis of Observational Studies.Frontiers in medicine · 2022Pooled it
- Association between physical activity and mortality in end-stage kidney disease: a systematic review of observational studies.BMC nephrology · 2021Pooled it
- Sedentary behavior and kidney function in adults: a narrative review.Wiener klinische Wochenschrift · 2021Pooled it
- Modifiable Lifestyle Factors for Primary Prevention of CKD: A Systematic Review and Meta-Analysis.Journal of the American Society of Nephrology : JASN · 2021Pooled it
- The Physical ACtivity Enhancement Scheme (PACES) improves physical activity level and well-being in persons with hemodialysis: a randomized controlled trial.BMC nephrology · 2026Trial
- Effectiveness of a BCW theory-based exercise adherence intervention protocol in Chinese maintenance hemodialysis patients: a randomized controlled trial.Frontiers in public health · 2025Trial
- Trial
- Proteomic profiling of protein expression changes after 3 months-exercise in ESRD patients on hemodialysis.BMC nephrology · 2023Trial
- Does Intradialytic Group Exercise Programme Influence Patient-Reported Outcomes, Laboratory Parameters, and Anthropometric Parameters in Maintenance Hemodialysis Patients? A Single-Group Repeated-Measures Trial.Patient preference and adherence · 2023Trial
- Cardiorenal syndrome and the association with fitness: Data from a telerehabilitation randomized clinical trial.ESC heart failure · 2022Trial
- The UP150: A Multifactorial Environmental Intervention to Promote Employee Physical and Mental Well-Being.International journal of environmental research and public health · 2022Trial
- Lifestyle intervention to improve quality of life and prevent weight gain after renal transplantation: Design of the Active Care after Transplantation (ACT) randomized controlled trial.BMC nephrology · 2017Trial
78 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Regular physical activity is associated with an increased quality of life and reduced morbidity and mortality in the general population and in patients with chronic kidney disease (CKD). Physical activity, cardiorespiratory fitness, and muscle mass decrease even in the early stages of CKD, and continue to decrease with disease progression; notably, full recovery is generally not achieved with transplantation. The combined effects of uraemia and physical inactivity drive the loss of muscle mass. Regular physical activity benefits cardiometabolic, neuromuscular and cognitive function across all stages of CKD, and therefore provides an approach to address the multimorbidity of the CKD population. Interestingly, maintenance of muscle health is associated with renoprotective effects. Despite evidence of its benefits, physical activity and exercise management are not routinely addressed in the care of these patients. Although studies defining the optimum frequency, duration and intensity of physical activity are lacking, evidence from related fields can guide practical approaches to the care of patients with renal disease. Optimization of metabolic and nutritional status alongside promotion of physical activity is recommended. Behavioural approaches are now recognized as crucial in helping patients to adopt lifestyle changes and might prove valuable in integrating physical activity into renal care.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.