Evidence map›Paper›PMID 28138098›Full record

ArticleJournal of bacteriology2017

Genetic and Mechanistic Analyses of the Periplasmic Domain of the Enterohemorrhagic Escherichia coli QseC Histidine Sensor Kinase.

Christopher T Parker, Regan Russell, Jacqueline W Njoroge, Angel G Jimenez, Ron Taussig, Vanessa Sperandio

Open access · bronzeAbstract read
In one paragraph

Article in Journal of bacteriology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Pangenome Analysis ofAntibiotics (Basel, Switzerland) · 2020
    Article
  5. Bacterial signaling as an antimicrobial target.Current opinion in microbiology · 2020
    Review
  6. The Role ofToxins · 2020
    Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Review
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  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Christopher T ParkerDepartment of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Regan RussellDepartment of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Jacqueline W NjorogeDepartment of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Angel G JimenezDepartment of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Ron TaussigDepartment of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Vanessa SperandioDepartment of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA vanessa.sperandio@utsouthwestern.edu.
The University of Texas Southwestern Medical Center · US

Funding

MOLECULAR MICROBIOLOGY TRAINING GRANTT32AI007520 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI Julie K Pfeiffer · 1997 to 2026
$7.0M
Quorum sensing regulation of EHEC virulence genesR01AI053067 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI SPERANDIO, VANESSA · 2003 to 2017
$6.3M
Quorum Sensing Regulation of EHEC Virulence GenesR37AI053067 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI VANESSA SPERANDIO · 2018 to 2026
$5.3M
SdiA regulation of EHEC virulenceR01AI077613 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI SPERANDIO, VANESSA · 2009 to 2017
$3.4M
Tryptophan derivatives in EHEC pathogenesisR01AI114511 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI SPERANDIO, VANESSA · 2015 to 2019
$2.3M
Sugar Regulation of EHEC virulenceR01AI105135 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI SPERANDIO, VANESSA · 2013 to 2016
$1.6M
NIAID NIH HHS R01 AI053067NIAID NIH HHS R01 AI077613NIAID NIH HHS R01 AI105135NIAID NIH HHS R01 AI114511NIAID NIH HHS R37 AI053067NIAID NIH HHS T32 AI007520
6 · The paper itself

Abstract

The histidine sensor kinase (HK) QseC senses autoinducer 3 (AI-3) and the adrenergic hormones epinephrine and norepinephrine. Upon sensing these signals, QseC acts through three response regulators (RRs) to regulate the expression of virulence genes in enterohemorrhagic

Indexed as

Escherichia coliEscherichia coli ProteinsEvolution, MolecularGene Expression Regulation, BacterialGene Expression Regulation, EnzymologicHeLa CellsHumansMutationPeriplasmEscherichia coli ProteinsQseC protein, E coliEHECenterohemorrhagic E. coliLEEQseCtwo-component system

Identifiers

PMID28138098
PMCPMC5370426
OpenAlexW2582803479

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.