ArticleMolecular biology and evolution2017
Evolution of Local Mutation Rate and Its Determinants.
Article in Molecular biology and evolution, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Mutational Signatures in Wild Type Escherichia coli Strains Reveal Predominance of DNA Polymerase Errors.Genome biology and evolution · 2024Article
- A mutation rate model at the basepair resolution identifies the mutagenic effect of polymerase III transcription.Nature genetics · 2023Article
- X-linked hydrocephalus genes: Their proximity to telomeres and high A + T content compared to Parkinson's disease.Experimental neurology · 2023Review
- Genomic diversity landscapes in outcrossing and selfing Caenorhabditis nematodes.PLoS genetics · 2023Article
- Article
- Mutation bias and the predictability of evolution.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Individual Genetic Heterogeneity.Genes · 2022Review
- Mutational Signatures of Replication Timing and Epigenetic Modification Persist through the Global Divergence of Mutation Spectra across the Great Ape Phylogeny.Genome biology and evolution · 2022Article
- Bottleneck-associated changes in the genomic landscape of genetic diversity in wild lynx populations.Evolutionary applications · 2021Article
- The origin of human mutation in light of genomic data.Nature reviews. Genetics · 2021Review
- Review
- Population sequencing data reveal a compendium of mutational processes in the human germ line.Science (New York, N.Y.) · 2021Article
- De Novo Mutation Rate Variation and Its Determinants in Chlamydomonas.Molecular biology and evolution · 2021Article
- Non-B DNA: a major contributor to small- and large-scale variation in nucleotide substitution frequencies across the genome.Nucleic acids research · 2021Article
- Identifying branch-specific positive selection throughout the regulatory genome using an appropriate proxy neutral.BMC genomics · 2020Article
- Nucleosome positioning stability is a modulator of germline mutation rate variation across the human genome.Nature communications · 2020Article
- Impact of Mutation Rate and Selection at Linked Sites on DNA Variation across the Genomes of Humans and Other Homininae.Genome biology and evolution · 2020Article
- What is mutation? A chapter in the series: How microbes "jeopardize" the modern synthesis.PLoS genetics · 2019Review
- Large scale variation in the rate of germ-line de novo mutation, base composition, divergence and diversity in humans.PLoS genetics · 2018Article
- APOBEC3A/B-induced mutagenesis is responsible for 20% of heritable mutations in the TpCpW context.Genome research · 2017Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mutation rate varies along the human genome, and part of this variation is explainable by measurable local properties of the DNA molecule. Moreover, mutation rates differ between orthologous genomic regions of different species, but the drivers of this change are unclear. Here, we use data on human divergence from chimpanzee, human rare polymorphism, and human de novo mutations to predict the substitution rate at orthologous regions of non-human mammals. We show that the local mutation rates are very similar between human and apes, implying that their variation has a strong underlying cryptic component not explainable by the known genomic features. Mutation rates become progressively less similar in more distant species, and these changes are partially explainable by changes in the local genomic features of orthologous regions, most importantly, in the recombination rate. However, they are much more rapid, implying that the cryptic component underlying the mutation rate is more ephemeral than the known genomic features. These findings shed light on the determinants of mutation rate evolution. Key words: local mutation rate, molecular evolution, recombination rate.
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