Evidence map›Paper›PMID 28138045›Full record

ArticleThe American journal of tropical medicine and hygiene2017

Clinical Comparison of Retinopathy-Positive and Retinopathy-Negative Cerebral Malaria.

Chandler Villaverde, Ruth Namazzi, Estela Shabani, Robert O Opoka, Chandy C John

Open access · bronzeAbstract readComparative Study
In one paragraph

Article in The American journal of tropical medicine and hygiene, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
4.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Pediatric Cerebral Malaria.Current tropical medicine reports · 2021
    Article
  11. Article
  12. Central Nervous System Virus Infection in African Children with Cerebral Malaria.The American journal of tropical medicine and hygiene · 2020
    Article
  13. Article
  14. Article
  15. Desperately Seeking Therapies for Cerebral Malaria.Journal of immunology (Baltimore, Md. : 1950) · 2020
    Review
  16. Review
  17. Article
  18. MRI demonstrates glutamine antagonist-mediated reversal of cerebral malaria pathology in mice.Proceedings of the National Academy of Sciences of the United States of America · 2018
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Chandler VillaverdeThe Warren Alpert Medical School, Brown University, Providence, Rhode Island.
Ruth NamazziDepartment of Paediatrics and Child Health, Makerere University College of Health Sciences, Kampala, Uganda.
Estela ShabaniDepartment of Pediatrics, University of Minnesota, Minneapolis, Minnesota.
Robert O OpokaDepartment of Paediatrics and Child Health, Makerere University College of Health Sciences, Kampala, Uganda.
Chandy C JohnDepartment of Pediatrics, University of Minnesota, Minneapolis, Minnesota.
Makerere University · UGBrown University · USIndiana University – Purdue University Indianapolis · USUniversity of Minnesota · US

Funding

Severe Malaria And Risk to The Brain (SMART Brain)R01NS055349 · NINDS · UNIVERSITY OF MINNESOTA · PI Chandy C. John, Ruth Namazzi · 2008 to 2026
$11.2M
Research Training in Infection and Neurodevelopment in UgandaD43NS078280 · NINDS · UNIVERSITY OF MINNESOTA · PI JOHN, CHANDY C. · 2011 to 2015
$1.1M
NINDS NIH HHS D43 NS078280NINDS NIH HHS R01 NS055349
6 · The paper itself

Abstract

AbstractCerebral malaria (CM) is a severe and often lethal complication of falciparum malaria. A classic malaria retinopathy is seen in some (retinopathy-positive [RP]) children but not others (retinopathy-negative [RN]), and is associated with increased parasite sequestration. It is unclear whether RN CM is a severe nonmalarial illness with incidental parasitemia or a less severe form of the same malarial illness as RP CM. Understanding the clinical differences between RP and RN CM may help shed light on the pathophysiology of malarial retinopathy. We compared clinical history, physical examination, laboratory findings, and outcomes of RP (

Indexed as

AntimalarialsBlood TransfusionChildChild, PreschoolCohort StudiesComaFemaleHumansInfantMalaria, CerebralMalaria, FalciparumMalePlasmodium falciparumRetinal DegenerationSeverity of Illness IndexTime FactorsAntimalarials

Identifiers

PMID28138045
PMCPMC5417214
OpenAlexW2582600798

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.