ArticleThe Journal of pharmacology and experimental therapeutics2017
Control of Neurotransmission by NaV1.7 in Human, Guinea Pig, and Mouse Airway Parasympathetic Nerves.
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Article in The Journal of pharmacology and experimental therapeutics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
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Who cites it
20 citing papers in PubMed, 27 citations in OpenAlex.
- Sensory neuron sodium channels as pain targets; from cocaine to Journavx (VX-548, suzetrigine).The Journal of general physiology · 2025Review
- Role of NaThe Journal of physiology · 2024Article
- Action potential conduction in the mouse and rat vagus nerve is dependent on multiple voltage-gated sodium channels (NaJournal of neurophysiology · 2023Article
- Inhibition of NaRSC medicinal chemistry · 2022Review
- Neuro-Immune Regulation in Inflammation and Airway Remodeling of Allergic Asthma.Frontiers in immunology · 2022Review
- Role of NaBritish journal of pharmacology · 2022Article
- Neural control of the lower airways: Role in cough and airway inflammatory disease.Handbook of clinical neurology · 2022Review
- Contribution of tetrodotoxin-sensitive, voltage-gated sodium channels (NaAmerican journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- Antitussive effects of NaEuropean journal of pharmacology · 2021Article
- The Changes in Expression of NaMembranes · 2021Article
- Voltage-gated sodium channels mediating conduction in vagal motor fibers innervating the esophageal striated muscle.Physiological research · 2020Article
- Stimulus intensity-dependent recruitment of NaAmerican journal of physiology. Gastrointestinal and liver physiology · 2020Article
- Pathophysiological roles and therapeutic potential of voltage-gated ion channels (VGICs) in pain associated with herpesvirus infection.Cell & bioscience · 2020Review
- Nuclear Factor-kappaB Gates NaiScience · 2019Article
- Airway Innervation and Plasticity in Asthma.Physiology (Bethesda, Md.) · 2019Review
- Different role of TTX-sensitive voltage-gated sodium channel (NaThe Journal of physiology · 2018Article
- Ozone-induced eosinophil recruitment to airways is altered by antigen sensitization and tumor necrosis factor-Physiological reports · 2017Article
- Newly divided eosinophils limit ozone-induced airway hyperreactivity in nonsensitized guinea pigs.American journal of physiology. Lung cellular and molecular physiology · 2017Article
- Sodium channels NaNeurobiology of pain (Cambridge, Mass.)Article
- Cell specific regulation of NaV1.7 activity and trafficking in rat nodose ganglia neurons.Neurobiology of pain (Cambridge, Mass.)Article
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Authors and funding
16 authors at 5 institutions in 3 countries.
Michaela KocmalovaThe Johns Hopkins University School of Medicine, Division of Allergy and Clinical Immunology, Baltimore, Maryland 21224 (M.Koc., M.Kol., B.J.C., F.R., R.A.H., S.M., B.J.U.); Biomedical Center Martin, Pharmacology and Pathophysiology, Jessenius Faculty of Medicine, Comenius University, Martin 03601, Slovakia (M.Koc., M.Kol.); Almirall S.A., R&D Research Center, Barcelona 08980, Spain (S.F., M.A., M.M.); and Lilly Research Laboratories, Indianapolis, Indiana 46285 (X.C., B.L., B.W., J.M., E.N., J.L.K.).
Marian KollarikThe Johns Hopkins University School of Medicine, Division of Allergy and Clinical Immunology, Baltimore, Maryland 21224 (M.Koc., M.Kol., B.J.C., F.R., R.A.H., S.M., B.J.U.); Biomedical Center Martin, Pharmacology and Pathophysiology, Jessenius Faculty of Medicine, Comenius University, Martin 03601, Slovakia (M.Koc., M.Kol.); Almirall S.A., R&D Research Center, Barcelona 08980, Spain (S.F., M.A., M.M.); and Lilly Research Laboratories, Indianapolis, Indiana 46285 (X.C., B.L., B.W., J.M., E.N., J.L.K.).
Brendan J CanningThe Johns Hopkins University School of Medicine, Division of Allergy and Clinical Immunology, Baltimore, Maryland 21224 (M.Koc., M.Kol., B.J.C., F.R., R.A.H., S.M., B.J.U.); Biomedical Center Martin, Pharmacology and Pathophysiology, Jessenius Faculty of Medicine, Comenius University, Martin 03601, Slovakia (M.Koc., M.Kol.); Almirall S.A., R&D Research Center, Barcelona 08980, Spain (S.F., M.A., M.M.); and Lilly Research Laboratories, Indianapolis, Indiana 46285 (X.C., B.L., B.W., J.M., E.N., J.L.K.).
Fei RuThe Johns Hopkins University School of Medicine, Division of Allergy and Clinical Immunology, Baltimore, Maryland 21224 (M.Koc., M.Kol., B.J.C., F.R., R.A.H., S.M., B.J.U.); Biomedical Center Martin, Pharmacology and Pathophysiology, Jessenius Faculty of Medicine, Comenius University, Martin 03601, Slovakia (M.Koc., M.Kol.); Almirall S.A., R&D Research Center, Barcelona 08980, Spain (S.F., M.A., M.M.); and Lilly Research Laboratories, Indianapolis, Indiana 46285 (X.C., B.L., B.W., J.M., E.N., J.L.K.).
R Adam HerbstsomerThe Johns Hopkins University School of Medicine, Division of Allergy and Clinical Immunology, Baltimore, Maryland 21224 (M.Koc., M.Kol., B.J.C., F.R., R.A.H., S.M., B.J.U.); Biomedical Center Martin, Pharmacology and Pathophysiology, Jessenius Faculty of Medicine, Comenius University, Martin 03601, Slovakia (M.Koc., M.Kol.); Almirall S.A., R&D Research Center, Barcelona 08980, Spain (S.F., M.A., M.M.); and Lilly Research Laboratories, Indianapolis, Indiana 46285 (X.C., B.L., B.W., J.M., E.N., J.L.K.).
Sonya MeekerThe Johns Hopkins University School of Medicine, Division of Allergy and Clinical Immunology, Baltimore, Maryland 21224 (M.Koc., M.Kol., B.J.C., F.R., R.A.H., S.M., B.J.U.); Biomedical Center Martin, Pharmacology and Pathophysiology, Jessenius Faculty of Medicine, Comenius University, Martin 03601, Slovakia (M.Koc., M.Kol.); Almirall S.A., R&D Research Center, Barcelona 08980, Spain (S.F., M.A., M.M.); and Lilly Research Laboratories, Indianapolis, Indiana 46285 (X.C., B.L., B.W., J.M., E.N., J.L.K.).
Silvia FonquernaThe Johns Hopkins University School of Medicine, Division of Allergy and Clinical Immunology, Baltimore, Maryland 21224 (M.Koc., M.Kol., B.J.C., F.R., R.A.H., S.M., B.J.U.); Biomedical Center Martin, Pharmacology and Pathophysiology, Jessenius Faculty of Medicine, Comenius University, Martin 03601, Slovakia (M.Koc., M.Kol.); Almirall S.A., R&D Research Center, Barcelona 08980, Spain (S.F., M.A., M.M.); and Lilly Research Laboratories, Indianapolis, Indiana 46285 (X.C., B.L., B.W., J.M., E.N., J.L.K.).
Monica ApariciThe Johns Hopkins University School of Medicine, Division of Allergy and Clinical Immunology, Baltimore, Maryland 21224 (M.Koc., M.Kol., B.J.C., F.R., R.A.H., S.M., B.J.U.); Biomedical Center Martin, Pharmacology and Pathophysiology, Jessenius Faculty of Medicine, Comenius University, Martin 03601, Slovakia (M.Koc., M.Kol.); Almirall S.A., R&D Research Center, Barcelona 08980, Spain (S.F., M.A., M.M.); and Lilly Research Laboratories, Indianapolis, Indiana 46285 (X.C., B.L., B.W., J.M., E.N., J.L.K.).
Montserrat MiralpeixThe Johns Hopkins University School of Medicine, Division of Allergy and Clinical Immunology, Baltimore, Maryland 21224 (M.Koc., M.Kol., B.J.C., F.R., R.A.H., S.M., B.J.U.); Biomedical Center Martin, Pharmacology and Pathophysiology, Jessenius Faculty of Medicine, Comenius University, Martin 03601, Slovakia (M.Koc., M.Kol.); Almirall S.A., R&D Research Center, Barcelona 08980, Spain (S.F., M.A., M.M.); and Lilly Research Laboratories, Indianapolis, Indiana 46285 (X.C., B.L., B.W., J.M., E.N., J.L.K.).
Xian Xuan ChiThe Johns Hopkins University School of Medicine, Division of Allergy and Clinical Immunology, Baltimore, Maryland 21224 (M.Koc., M.Kol., B.J.C., F.R., R.A.H., S.M., B.J.U.); Biomedical Center Martin, Pharmacology and Pathophysiology, Jessenius Faculty of Medicine, Comenius University, Martin 03601, Slovakia (M.Koc., M.Kol.); Almirall S.A., R&D Research Center, Barcelona 08980, Spain (S.F., M.A., M.M.); and Lilly Research Laboratories, Indianapolis, Indiana 46285 (X.C., B.L., B.W., J.M., E.N., J.L.K.).
Baolin LiThe Johns Hopkins University School of Medicine, Division of Allergy and Clinical Immunology, Baltimore, Maryland 21224 (M.Koc., M.Kol., B.J.C., F.R., R.A.H., S.M., B.J.U.); Biomedical Center Martin, Pharmacology and Pathophysiology, Jessenius Faculty of Medicine, Comenius University, Martin 03601, Slovakia (M.Koc., M.Kol.); Almirall S.A., R&D Research Center, Barcelona 08980, Spain (S.F., M.A., M.M.); and Lilly Research Laboratories, Indianapolis, Indiana 46285 (X.C., B.L., B.W., J.M., E.N., J.L.K.).
Ben WilenkinThe Johns Hopkins University School of Medicine, Division of Allergy and Clinical Immunology, Baltimore, Maryland 21224 (M.Koc., M.Kol., B.J.C., F.R., R.A.H., S.M., B.J.U.); Biomedical Center Martin, Pharmacology and Pathophysiology, Jessenius Faculty of Medicine, Comenius University, Martin 03601, Slovakia (M.Koc., M.Kol.); Almirall S.A., R&D Research Center, Barcelona 08980, Spain (S.F., M.A., M.M.); and Lilly Research Laboratories, Indianapolis, Indiana 46285 (X.C., B.L., B.W., J.M., E.N., J.L.K.).
Jeff McDermottThe Johns Hopkins University School of Medicine, Division of Allergy and Clinical Immunology, Baltimore, Maryland 21224 (M.Koc., M.Kol., B.J.C., F.R., R.A.H., S.M., B.J.U.); Biomedical Center Martin, Pharmacology and Pathophysiology, Jessenius Faculty of Medicine, Comenius University, Martin 03601, Slovakia (M.Koc., M.Kol.); Almirall S.A., R&D Research Center, Barcelona 08980, Spain (S.F., M.A., M.M.); and Lilly Research Laboratories, Indianapolis, Indiana 46285 (X.C., B.L., B.W., J.M., E.N., J.L.K.).
Eric NisenbaumThe Johns Hopkins University School of Medicine, Division of Allergy and Clinical Immunology, Baltimore, Maryland 21224 (M.Koc., M.Kol., B.J.C., F.R., R.A.H., S.M., B.J.U.); Biomedical Center Martin, Pharmacology and Pathophysiology, Jessenius Faculty of Medicine, Comenius University, Martin 03601, Slovakia (M.Koc., M.Kol.); Almirall S.A., R&D Research Center, Barcelona 08980, Spain (S.F., M.A., M.M.); and Lilly Research Laboratories, Indianapolis, Indiana 46285 (X.C., B.L., B.W., J.M., E.N., J.L.K.).
Jeffrey L KrajewskiThe Johns Hopkins University School of Medicine, Division of Allergy and Clinical Immunology, Baltimore, Maryland 21224 (M.Koc., M.Kol., B.J.C., F.R., R.A.H., S.M., B.J.U.); Biomedical Center Martin, Pharmacology and Pathophysiology, Jessenius Faculty of Medicine, Comenius University, Martin 03601, Slovakia (M.Koc., M.Kol.); Almirall S.A., R&D Research Center, Barcelona 08980, Spain (S.F., M.A., M.M.); and Lilly Research Laboratories, Indianapolis, Indiana 46285 (X.C., B.L., B.W., J.M., E.N., J.L.K.).
Bradley J UndemThe Johns Hopkins University School of Medicine, Division of Allergy and Clinical Immunology, Baltimore, Maryland 21224 (M.Koc., M.Kol., B.J.C., F.R., R.A.H., S.M., B.J.U.); Biomedical Center Martin, Pharmacology and Pathophysiology, Jessenius Faculty of Medicine, Comenius University, Martin 03601, Slovakia (M.Koc., M.Kol.); Almirall S.A., R&D Research Center, Barcelona 08980, Spain (S.F., M.A., M.M.); and Lilly Research Laboratories, Indianapolis, Indiana 46285 (X.C., B.L., B.W., J.M., E.N., J.L.K.) bundem@jhmi.edu.
Comenius University Bratislava · SKEli Lilly (United States) · USJohns Hopkins University · USAlmirall (Spain) · ESJohns Hopkins Medicine · US
Funding
Control of Airway Sensory Nerve Function by Voltage-Gated Sodium Channel SubtypesR01HL122228 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI UNDEM, BRADLEY JOEL · 2014 to 2020
$3.2MNHLBI NIH HHS R01 HL122228
Abstract
Little is known about the neuronal voltage-gated sodium channels (NaVs) that control neurotransmission in the parasympathetic nervous system. We evaluated the expression of the
Indexed as
AnimalsDose-Response Relationship, DrugGanglia, ParasympatheticGuinea PigsHEK293 CellsHumansLungMaleMiceMuscle, SmoothNAV1.7 Voltage-Gated Sodium ChannelOrgan Culture TechniquesParasympathetic Fibers, PostganglionicSodium Channel BlockersSynaptic TransmissionNAV1.7 Voltage-Gated Sodium ChannelSCN9A protein, humanSodium Channel Blockers
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