Evidence map›Paper›PMID 28138022›Full record

ArticleInfection and immunity2017

The Severity of Plasmodium falciparum Infection Is Associated with Transcript Levels of

Sixbert I Mkumbaye, Christian W Wang, Eric Lyimo, Jakob S Jespersen, Alphaxard Manjurano, Jacklin Mosha, Reginald A Kavishe, Steven B Mwakalinga, Daniel T R Minja, John P Lusingu and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Infection and immunity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 1 pooled it
12.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 1 synthesis or guideline pooled it, 82 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Article
  7. Evasive mechanisms of human VSG and PfEMP1 antigens with link to Vaccine scenario: a review.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2025
    Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Broadly inhibitory antibodies against severe malaria virulence proteins.bioRxiv : the preprint server for biology · 2024
    Article
  13. Review
  14. Review
  15. Article
  16. Diagnosis of cerebral malaria: Tools to reduceFrontiers in cellular and infection microbiology · 2023
    Review
  17. Article
  18. Review
  19. Article
  20. Frontiers in cellular and infection microbiology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Sixbert I MkumbayeKilimanjaro Christian Medical University College and Kilimanjaro Clinical Research Institute, Moshi, Tanzania.
Christian W WangCentre for Medical Parasitology, Department of International Health, Immunology and Microbiology, University of Copenhagen, and Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark.
Eric LyimoNational Institute for Medical Research, Mwanza Research Centre, Mwanza, Tanzania.
Jakob S JespersenCentre for Medical Parasitology, Department of International Health, Immunology and Microbiology, University of Copenhagen, and Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark.
Alphaxard ManjuranoNational Institute for Medical Research, Mwanza Research Centre, Mwanza, Tanzania.
Jacklin MoshaNational Institute for Medical Research, Mwanza Research Centre, Mwanza, Tanzania.
Reginald A KavisheKilimanjaro Christian Medical University College and Kilimanjaro Clinical Research Institute, Moshi, Tanzania.
Steven B MwakalingaKilimanjaro Christian Medical University College and Kilimanjaro Clinical Research Institute, Moshi, Tanzania.
Daniel T R MinjaNational Institute for Medical Research, Tanga Research Centre, Tanga, Tanzania.
John P LusinguNational Institute for Medical Research, Tanga Research Centre, Tanga, Tanzania.
Thor G TheanderCentre for Medical Parasitology, Department of International Health, Immunology and Microbiology, University of Copenhagen, and Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark.
Thomas LavstsenCentre for Medical Parasitology, Department of International Health, Immunology and Microbiology, University of Copenhagen, and Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark thomasl@sund.ku.dk.ORCID http://orcid.org/0000-0002-3044-4249
National Institute for Medical Research · TZUniversity of Copenhagen · DKKilimanjaro Christian Medical Centre · TZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

By attaching infected erythrocytes to the vascular lining,

Indexed as

Gene Expression RegulationTranscription, GeneticBiomarkersChildChild, PreschoolHumansInfantMalaria, FalciparumPlasmodium falciparumProtein Interaction Domains and MotifsProtozoan ProteinsSeverity of Illness IndexTanzaniaBiomarkerserythrocyte membrane protein 1, Plasmodium falciparumProtozoan Proteinsantigenic variationgene expressionmalariaPfEMP1Plasmodium falciparum

Identifiers

PMID28138022
PMCPMC5364309
OpenAlexW2582924274

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.