Evidence map›Paper›PMID 28138020›Full record

ArticleInfection and immunity2017

The Type II Secretion System of Legionella pneumophila Dampens the MyD88 and Toll-Like Receptor 2 Signaling Pathway in Infected Human Macrophages.

Celeste A Mallama, Kessler McCoy-Simandle, Nicholas P Cianciotto

Open access · bronzeAbstract read
In one paragraph

Article in Infection and immunity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
4.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 46 citations in OpenAlex.

  1. Mucin stimulates the growth ofMicrobiology (Reading, England) · 2026
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  2. Molecular evolution and adaptations ofFrontiers in cellular and infection microbiology · 2026
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  3. mBio · 2025
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  7. Protein sociology of ProA, Mip and other secreted virulence factors at theFrontiers in cellular and infection microbiology · 2023
    Review
  8. Review
  9. Article
  10. Review
  11. Microbial warfare in the wild-the impact of protists on the evolution and virulence of bacterial pathogens.International microbiology : the official journal of the Spanish Society for Microbiology · 2021
    Review
  12. Article
  13. The Role of Lipids inInternational journal of molecular sciences · 2021
    Review
  14. Review
  15. Article
  16. Article
  17. A Network Pharmacology Approach to Explore the Mechanisms of Shugan Jianpi Formula in Liver Fibrosis.Evidence-based complementary and alternative medicine : eCAM · 2020
    Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Celeste A MallamaDepartment of Microbiology and Immunology, Northwestern University Medical School, Chicago, Illinois, USA.
Kessler McCoy-SimandleDepartment of Microbiology and Immunology, Northwestern University Medical School, Chicago, Illinois, USA.
Nicholas P CianciottoDepartment of Microbiology and Immunology, Northwestern University Medical School, Chicago, Illinois, USA n-cianciotto@northwestern.edu.
Northwestern University · US

Funding

TYPE II SECRETION AND LEGIONELLA PNEUMOPHILA INFECTIONR01AI043987 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CIANCIOTTO, NICHOLAS P · 1999 to 2017
$4.8M
NIAID NIH HHS R01 AI043987
6 · The paper itself

Abstract

Previously, we reported that mutants of

Indexed as

Type II Secretion SystemsAnimalsCell LineCells, CulturedCytokineseIF-2 KinaseHumansInflammasomesLegionella pneumophilaMacrophagesMiceMitogen-Activated Protein KinasesMyeloid Differentiation Factor 88NF-kappa BSignal TransductionToll-Like Receptor 2CytokinesEIF2AK2 protein, humaneIF-2 KinaseInflammasomesMitogen-Activated Protein KinasesMyeloid Differentiation Factor 88NF-kappa BToll-Like Receptor 2Type II Secretion Systemscytokineinnate immunityLegionella pneumophilamacrophageTLR2type II secretion

Identifiers

PMID28138020
PMCPMC5364298
OpenAlexW2581299651

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.