ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2017
A Critical Role for Astrocytes in Hypercapnic Vasodilation in Brain.
Erratum issued Registry-linked trialOpen access · bronzeAbstract read
In one paragraph
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT03923283 (End-tidal Carbondioxide Levels Under Surgery Drapes During Local Eye Surgery), which is not on this map. Cited by 49 papers.
0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
End-tidal Carbondioxide Levels Under Surgery Drapes During Local Eye Surgery: Retrospective Study
Who cites it
49 citing papers in PubMed, 85 citations in OpenAlex.
- APOE gene-dependent BOLD responses to a breath-hold across the adult lifespan.NeuroImage. Clinical · 2019Trial
- Review
- Molecular and Cellular Signaling Pathways of the Effects of Hypoxia and Hypercapnia on the Mechanisms of Neuroinflammation.International journal of molecular sciences · 2026Review
- Capillary-Associated Microglia in Neurovascular Coupling: Localization, Mechanisms, and Disease Implications.Journal of neuroinflammation · 2026Review
- Targeting Reactive Astrocytes with Flavonoids to Alleviate Neuroinflammation and Promote Synaptic Function.Molecular neurobiology · 2026Review
- Lower cerebral blood flow but not cerebrovascular response in elastin haploinsufficient mice.Experimental physiology · 2026Article
- Neurovascular coupling and cerebrovascular reactivity: physiology, lifespan development, pathophysiology, and clinical relevance.Frontiers in physiology · 2026Review
- Retrotrapezoid nucleus chemoreception: mechanisms of function and contributions to disordered breathing in disease.Trends in neurosciences · 2025Review
- Development of perivascular astrocyte processes.Frontiers in neuroscience · 2025Review
- Modeling of Blood Flow Dynamics in Rat Somatosensory Cortex.Biomedicines · 2024Article
- Microglia contact cerebral vasculature through gaps between astrocyte endfeet.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Neurovascular coupling and CONature communications · 2024Article
- Respiratory neuropathology in spinocerebellar ataxia type 7.JCI insight · 2024Article
- Metabolic trade-offs in Neonatal sepsis triggered by TLR4 and TLR1/2 ligands result in unique dysfunctions in neural breathing circuits.Brain, behavior, and immunity · 2024Article
- Multicore fiber optic imaging reveals that astrocyte calcium activity in the mouse cerebral cortex is modulated by internal motivational state.Nature communications · 2024Article
- Astrocyte Regulation of Cerebral Blood Flow in Health and Disease.Cold Spring Harbor perspectives in biology · 2024Review
- Astrocytes: new evidence, new models, new roles.Biophysical reviews · 2023Review
- The astrocytic NaThe Journal of physiology · 2023Article
- Modeling the relationship between neuronal activity and the BOLD signal: contributions from astrocyte calcium dynamics.Scientific reports · 2023Article
- Article
Corrections and comments
- Erratum issued
Authors and funding
14 authors at 5 institutions in 4 countries.
Clare HowarthDjavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.ORCID 0000-0002-6660-9770
Brad SutherlandAcute Stroke Programme, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, United Kingdom.ORCID 0000-0002-0791-0950
Hyun B ChoiDjavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.ORCID 0000-0003-2405-4428
Chris MartinCancer Research United Kingdom and Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, OX3 7DQ, United Kingdom.ORCID 0000-0002-8186-784X
Barbara Lykke LindDepartment of Neuroscience and Pharmacology and Center for Healthy Aging, University of Copenhagen, DK-2200 Copenhagen N, Denmark.
Lila KhennoufDepartment of Neuroscience and Pharmacology and Center for Healthy Aging, University of Copenhagen, DK-2200 Copenhagen N, Denmark.ORCID 0000-0001-6078-7819
Jeffrey M LeDueDjavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.
Janelle M P PakanDjavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.ORCID 0000-0001-9384-8067
Rebecca W Y KoDjavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.ORCID 0000-0003-0339-8336
Graham Ellis-DaviesDepartment of Neuroscience, Mount Sinai School of Medicine, New York, New York 10028, and.
Martin LauritzenDepartment of Neuroscience and Pharmacology and Center for Healthy Aging, University of Copenhagen, DK-2200 Copenhagen N, Denmark.ORCID 0000-0002-1517-1131
Nicola R SibsonCancer Research United Kingdom and Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, OX3 7DQ, United Kingdom.
Alastair M BuchanAcute Stroke Programme, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, United Kingdom, bmacvicar@brain.ubc.ca alastair.buchan@medsci.ox.ac.uk.ORCID 0000-0002-2918-5200
Brian A MacVicarDjavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada, bmacvicar@brain.ubc.ca alastair.buchan@medsci.ox.ac.uk.
University of British Columbia · CAUniversity of Copenhagen · DKUniversity of Oxford · GBIcahn School of Medicine at Mount Sinai · USJohn Radcliffe Hospital · GB
Funding
PHOTOCHEMICAL REGULATION OF CALCIUM IN CELL PHYSIOLOGYR01GM053395 · NIGMS · OREGON HEALTH AND SCIENCE UNIVERSITY · PI ELLIS-DAVIES, GRAHAM · 1995 to 2020
$6.1MOptical probes for controlling cellular functionR01NS069720 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ELLIS-DAVIES, GRAHAM · 2010 to 2017
$3.2MStructure-Function Relationships of Experience-Dependent Spine PlasticityR21EY026702 · NEI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ELLIS-DAVIES, GRAHAM, MORISHITA, HIROFUMI · 2017 to 2018
$461kCancer Research UK 16945Cancer Research UK C5255/A12678CIHR 115121CIHR 148397CIHR 8545Medical Research Council G0401355NEI NIH HHS R21 EY026702NIGMS NIH HHS R01 GM053395NINDS NIH HHS R01 NS069720Wellcome Trust
Abstract
Cerebral blood flow (CBF) is controlled by arterial blood pressure, arterial CO
Indexed as
Adrenergic alpha-2 Receptor AgonistsAdrenergic alpha-AgonistsAnimalsAnimals, NewbornAstrocytesCarbon DioxideCerebrovascular CirculationClonidineCycloleucineCyclooxygenase 1DinoprostoneFemaleGlial Fibrillary Acidic ProteinGlutathioneHippocampusHypercapnia1-amino-1,3-dicarboxycyclopentaneAdrenergic alpha-2 Receptor AgonistsAdrenergic alpha-AgonistsCarbon DioxideClonidineCycloleucineCyclooxygenase 1DinoprostoneGlial Fibrillary Acidic ProteinGlutathioneMembrane ProteinsNeuroprotective AgentsNorepinephrinePtgs1 protein, mouseastrocytecalciumcerebral blood flowglutathionehypercapnia
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
NCT03923283ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.