ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2017
Identification of the Upward Movement of Human CSF
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 125 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
125 citing papers in PubMed, 1 synthesis or guideline pooled it, 214 citations in OpenAlex.
- Obstructive sleep apnea, cognition and Alzheimer's disease: A systematic review integrating three decades of multidisciplinary research.Sleep medicine reviews · 2020Pooled it
- Immediate impact of yogic breathing on pulsatile cerebrospinal fluid dynamics.Scientific reports · 2022Trial
- Flow 2.0: A Standardized Toolbox for Real-Time Phase-Contrast MRI of Neurofluid Dynamics.Magnetic resonance in medicine · 2026Article
- Infra-slow (<0.1 Hz) Modulation of Human Brain Pulsations in Awake and Sleep States.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- MRI-based evidence of rectus capitis posterior minor hypertrophy and its correlation with disease duration in Parkinson's disease.BMC medical imaging · 2026Article
- Glymphatic system impairment in neurological disorders: potential mechanisms and therapeutic targets.Molecular biomedicine · 2026Review
- Real-time phase-contrast MRI can be used to quantify cerebrovascular reserve capacity - a comparative study to neurovascular ultrasound in healthy subjects.Neuroimage. Reports · 2026Article
- Simultaneous Real-time Imaging of Neurofluid and Neurovascular Dynamics Using Ultrafast Flow-weighted Echo-Planar Imaging.bioRxiv : the preprint server for biology · 2026Article
- Simultaneous real-time imaging of upper cervical cerebrospinal fluid and vascular dynamics using ultrafast inflow-weighted EPI.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- Glymphatic-meningeal lymphatic system imbalance: a peripheral-to-central inflammatory bridge in perioperative neurocognitive disorders.Frontiers in immunology · 2026Review
- Measuring CSF net velocity in the human subarachnoid space with 7T MRI: testing the classical view of CSF absorption.Fluids and barriers of the CNS · 2025Article
- Human cerebrospinal fluid net flow enhanced by respiration during the awake state.Nature communications · 2025Article
- Effect of organismal rhythmic activity on Aβ clearance by the glymphatic system.European journal of medical research · 2025Review
- Temporal and spatial characterization of physiological noise in rs-fMRI at a high temporal resolution.Scientific reports · 2025Article
- A mechanistic approach for intracranial pressure (ICP) level estimation.Scientific reports · 2025Article
- Amplitude fluctuations of cerebrovascular oscillations and CSF movement desynchronize during NREM3 sleep.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2025Article
- Orexin effect on physiological pulsations of the human brain.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Ultrafast Imaging of Physiological Brain Pulsations With Magnetic Resonance Encephalography-From Noise to Predictive Clinical Biomarker.NMR in biomedicine · 2025Review
- Modeling dynamic inflow effects in fMRI to quantify cerebrospinal fluid flow.bioRxiv : the preprint server for biology · 2025Article
- Assessing the feasibility of a new approach to measure the full spectrum of cerebrospinal fluid dynamics within the human brain using MRI: insights from a simulation study.Interface focus · 2025Article
65 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
CSF flux is involved in the pathophysiology of neurodegenerative diseases and cognitive impairment after traumatic brain injury, all hallmarked by the accumulation of cellular metabolic waste. Its effective disposal via various CSF routes has been demonstrated in animal models. In contrast, the CSF dynamics in humans are still poorly understood. Using novel real-time MRI, forced inspiration has been identified recently as a main driving force of CSF flow in the human brain. Exploiting technical advances toward real-time phase-contrast MRI, the current work analyzed directions, velocities, and volumes of human CSF flow within the brain aqueduct as part of the internal ventricular system and in the spinal canal during respiratory cycles. A consistent upward CSF movement toward the brain in response to forced inspiration was seen in all subjects at the aqueduct, in 11/12 subjects at thoracic level 2, and in 4/12 subjects at thoracic level 5. Concomitant analyses of CSF dynamics and cerebral venous blood flow, that is, in epidural veins at cervical level 3, uniquely demonstrated CSF and venous flow to be closely communicating cerebral fluid systems in which inspiration-induced downward flow of venous blood due to reduced intrathoracic pressure is counterbalanced by an upward movement of CSF. The results extend our understanding of human CSF flux and open important clinical implications, including concepts for drug delivery and new classifications and therapeutic options for various forms of hydrocephalus and idiopathic intracranial hypertension.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.