Evidence map›Paper›PMID 28137877›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

CaMKII modulates sodium current in neurons from epileptic

Christopher H Thompson, Nicole A Hawkins, Jennifer A Kearney, Alfred L George

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 45 citations in OpenAlex.

  1. mTORC2-NaChannels (Austin, Tex.) · 2026
    Article
  2. Review
  3. Review
  4. Inhibition of the GSK3β/Nav1.6 complex suppresses early-stage Alzheimer's hyperexcitability.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. DecipheringArXiv · 2024
    Article
  9. Article
  10. Voltage-Gated NaLife (Basel, Switzerland) · 2023
    Review
  11. T-type CaCell reports · 2023
    Article
  12. Strain-dependent effects on neurobehavioral and seizure phenotypes inbioRxiv : the preprint server for biology · 2023
    Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Properties of Calmodulin Binding to NaNeurochemical research · 2021
    Article
  18. Behavioral Deficits in Mice with Postnatal Disruption ofCerebral cortex communications · 2021
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Christopher H ThompsonDepartment of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611 christopher.thompson1@northwestern.edu.
Nicole A HawkinsDepartment of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.
Jennifer A KearneyDepartment of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.
Alfred L GeorgeDepartment of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.
Northwestern University · US

Funding

Combined Approach to the Genetic Basis of EpilepsyR01NS053792 · NINDS · VANDERBILT UNIVERSITY · PI KEARNEY, JENNIFER A · 2006 to 2019
$4.7M
HEREDITARY DEFECTS IN HUMAN SODIUM CHANNELSR01NS032387 · NINDS · VANDERBILT UNIVERSITY · PI GEORGE, ALFRED L. · 1994 to 2015
$3.2M
Hereditary Defects in Human Sodium ChannelsR37NS032387 · NINDS · VANDERBILT UNIVERSITY · PI GEORGE, ALFRED L. · 2003 to 2009
$2.6M
NINDS NIH HHS R01 NS032387NINDS NIH HHS R01 NS053792NINDS NIH HHS R37 NS032387
6 · The paper itself

Abstract

Monogenic epilepsies with wide-ranging clinical severity have been associated with mutations in voltage-gated sodium channel genes. In the

Indexed as

AnimalsCalcium-Calmodulin-Dependent Protein Kinase Type 2EpilepsyHEK293 CellsHippocampusHumansMembrane PotentialsMice, Inbred C57BLMice, Inbred StrainsMice, TransgenicMutationNAV1.2 Voltage-Gated Sodium ChannelNeuronsPatch-Clamp TechniquesSodiumCalcium-Calmodulin-Dependent Protein Kinase Type 2NAV1.2 Voltage-Gated Sodium ChannelSodiumCaMKIIepilepsyvoltage-gated sodium channel

Identifiers

PMID28137877
PMCPMC5321040
OpenAlexW2581622342

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.