ArticleProceedings of the National Academy of Sciences of the United States of America2017
IgD class switching is initiated by microbiota and limited to mucosa-associated lymphoid tissue in mice.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 55 citations in OpenAlex.
- Biomarker expression level changes within rectal gut-associated lymphoid tissues in spinal cord-injured rats.ImmunoHorizons · 2025Article
- Interleukin-1 signaling and CD4Frontiers in immunology · 2025Article
- IgT and IgD dominance in the teleost central nervous system.Frontiers in immunology · 2025Article
- CCR7A defines a subpopulation of IgDFrontiers in immunology · 2025Article
- Immunoglobulin class-switch recombination: Mechanism, regulation, and related diseases.MedComm · 2024Review
- Causal role of immune cells in obstructive sleep apnea hypopnea syndrome: Mendelian randomization study.World journal of clinical cases · 2024Article
- IgDPathogens (Basel, Switzerland) · 2024Article
- Essential role of MFSD1-GLMP-GIMAP5 in lymphocyte survival and liver homeostasis.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Essential requirement for IER3IP1 in B cell development.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Teleost IgDiScience · 2023Article
- In Search of Clinical Markers: Indicators of Exposure in Dampness and Mold Hypersensitivity Syndrome (DMHS).Journal of fungi (Basel, Switzerland) · 2023Article
- The Development of Gut Microbiota and Its Changes FollowingVaccines · 2023Review
- Rad52 mediates class-switch DNA recombination to IgD.Nature communications · 2022Article
- B cells promote CD8 T cell primary and memory responses to subunit vaccines.Cell reports · 2021Article
- SLFN2 protection of tRNAs from stress-induced cleavage is essential for T cell-mediated immunity.Science (New York, N.Y.) · 2021Article
- The Impact of SARS-CoV-2 on the Human Immune System and Microbiome.Infectious microbes & diseases · 2021Article
- B Cell Mobilization, Dissemination, Fine Tuning of Local Antigen Specificity and Isotype Selection in Asthma.Frontiers in immunology · 2021Article
- V(D)J recombination, somatic hypermutation and class switch recombination of immunoglobulins: mechanism and regulation.Immunology · 2020Review
- Rethinking mucosal antibody responses: IgM, IgG and IgD join IgA.Nature reviews. Immunology · 2020Review
- Essential requirement for nicastrin in marginal zone and B-1 B cell development.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
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19 authors at 2 institutions in 1 country.
Funding
Abstract
Class-switch recombination (CSR) alters the Ig isotype to diversify antibody effector functions. IgD CSR is a rare event, and its regulation is poorly understood. We report that deficiency of 53BP1, a DNA damage-response protein, caused age-dependent overproduction of secreted IgD resulting from increased IgD CSR exclusively within B cells of mucosa-associated lymphoid tissues. IgD overproduction was dependent on activation-induced cytidine deaminase, hematopoietic MyD88 expression, and an intact microbiome, against which circulating IgD, but not IgM, was reactive. IgD CSR occurred via both alternative nonhomologous end-joining and homologous recombination pathways. Microbiota-dependent IgD CSR also was detected in nasal-associated lymphoid tissue of WT mice. These results identify a pathway, present in WT mice and hyperactivated in 53BP1-deficient mice, by which microbiota signal via Toll-like receptors to elicit IgD CSR.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.