Evidence map›Paper›PMID 28137816›Full record

ArticleAntimicrobial agents and chemotherapy2017

Effects of Tedizolid Phosphate on Survival Outcomes and Suppression of Production of Staphylococcal Toxins in a Rabbit Model of Methicillin-Resistant Staphylococcus aureus Necrotizing Pneumonia.

Vien T M Le, Hoan N Le, Marcos Gabriel Pinheiro, Kenneth J Hahn, Mary L Dinh, Kajal B Larson, Shawn D Flanagan, Cedric Badiou, Gerard Lina, Christine Tkaczyk and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Antibiotic Resistance and the MRSA Problem.Microbiology spectrum · 2019
    Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Vien T M LeDivision of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California, San Francisco, California, USA.
Hoan N LeDivision of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California, San Francisco, California, USA.
Marcos Gabriel PinheiroDivision of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California, San Francisco, California, USA.
Kenneth J HahnDivision of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California, San Francisco, California, USA.
Mary L DinhDivision of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California, San Francisco, California, USA.
Kajal B LarsonMerck & Co., Inc., Kenilworth, New Jersey, USA.
Shawn D FlanaganMerck & Co., Inc., Kenilworth, New Jersey, USA.
Cedric BadiouINSERM U1111, Université Lyon 1, CNRS UMR5308, ENS Lyon, Lyon, France.
Gerard LinaINSERM U1111, Université Lyon 1, CNRS UMR5308, ENS Lyon, Lyon, France.
Christine TkaczykDepartment of Infectious Diseases, MedImmune, Gaithersburg, Maryland, USA.
Bret R SellmanDepartment of Infectious Diseases, MedImmune, Gaithersburg, Maryland, USA.
Binh An DiepDivision of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California, San Francisco, California, USA binh.diep@ucsf.edu.
University of California, San Francisco · USMerck & Co., Inc., Rahway, NJ, USA (United States) · USCentre National de la Recherche Scientifique · FRInserm · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The protective efficacy of tedizolid phosphate, a novel oxazolidinone that potently inhibits bacterial protein synthesis, was compared to those of linezolid, vancomycin, and saline in a rabbit model of

Indexed as

AnimalsAnti-Bacterial AgentsLinezolidMethicillin-Resistant Staphylococcus aureusMicrobial Sensitivity TestsOrganophosphatesOxazolesPneumonia, NecrotizingPneumonia, StaphylococcalRabbitsStaphylococcus aureusVancomycinAnti-Bacterial AgentsLinezolidOrganophosphatesOxazolestedizolid phosphateVancomycinalpha-toxinlinezolidpneumoniaPVLrabbit modeltedizolidvancomycin

Identifiers

PMID28137816
PMCPMC5365717
OpenAlexW2583079032

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.