Evidence map›Paper›PMID 28137808›Full record

ArticleAntimicrobial agents and chemotherapy2017

Two Novel Calcium-Dependent Protein Kinase 1 Inhibitors Interfere with Vertical Transmission in Mice Infected with Neospora caninum Tachyzoites.

Joachim Müller, Adriana Aguado-Martínez, Vreni Balmer, Dustin J Maly, Erkang Fan, Luis-Miguel Ortega-Mora, Kayode K Ojo, Wesley C Van Voorhis, Andrew Hemphill

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.0field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
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  3. Treatment with BKI-1748 afterAntimicrobial agents and chemotherapy · 2025
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  8. Common Molecular Targets of a Quinolone Based Bumped Kinase Inhibitor inInternational journal of molecular sciences · 2022
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Microorganisms · 2020
    Article
  16. Pathogens (Basel, Switzerland) · 2020
    Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Joachim MüllerInstitute of Parasitology, Vetsuisse Faculty, University of Bern, Bern, Switzerland.
Adriana Aguado-MartínezInstitute of Parasitology, Vetsuisse Faculty, University of Bern, Bern, Switzerland.
Vreni BalmerInstitute of Parasitology, Vetsuisse Faculty, University of Bern, Bern, Switzerland.
Dustin J MalyDepartment of Chemistry, University of Washington, Seattle, Washington, USA.
Erkang FanDepartment of Biochemistry, University of Washington, Seattle, Washington, USA.
Luis-Miguel Ortega-MoraSALUVET, Animal Health Department, Faculty of Veterinary Sciences, Complutense University of Madrid, Madrid, Spain.
Kayode K OjoCenter for Emerging and Reemerging Infectious Diseases, Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, USA.
Wesley C Van VoorhisCenter for Emerging and Reemerging Infectious Diseases, Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, USA.
Andrew HemphillInstitute of Parasitology, Vetsuisse Faculty, University of Bern, Bern, Switzerland andrew.hemphill@vetsuisse.unibe.ch.
University of Bern · CHUniversity of Washington · USUniversidad Complutense de Madrid · ES

Funding

Bumped Kinase Inhibitors: Novel Therapeutics for Cryptosporidiosis&ToxoplasmosisR01AI111341 · NIAID · UNIVERSITY OF WASHINGTON · PI VAN VOORHIS, WESLEY C · 2014 to 2018
$6.4M
Calcium Dependent Protein Kinase 1 as a drug target for T. gondii and C. parvumR01AI089441 · NIAID · UNIVERSITY OF WASHINGTON · PI MERRITT, ETHAN A, PARSONS, MARILYN · 2010 to 2014
$5.0M
Dual Use Therapeutics for Cryptosporidiosis, Toxoplasmosis, and NeosporosisR01HD080670 · NICHD · UNIVERSITY OF WASHINGTON · PI VAN VOORHIS, WESLEY C · 2014 to 2018
$1.9M
NIAID NIH HHS R01 AI089441NIAID NIH HHS R01 AI111341NICHD NIH HHS R01 HD080670
6 · The paper itself

Abstract

We present the effects of two novel bumped kinase inhibitors, BKI-1517 and BKI-1553, against

Indexed as

Animalsbeta-GalactosidaseBrainCell ProliferationCoccidiosisCoccidiostatsFemaleFertilityFibroblastsGene ExpressionGenes, ReporterHumansInfectious Disease Transmission, VerticalLife Cycle StagesMiceMice, Inbred BALB Cbeta-GalactosidaseBK-1517BKI-1553CoccidiostatsOxazinesProtein Kinase InhibitorsProtein KinasesProtozoan ProteinsPyrazolesPyrimidinesQuinolinesresazurinXanthenesapicomplexan parasitesbumped kinase inhibitorcalcium-dependent protein kinasechemotherapyfertilityNeospora caninumpregnant mouse modelvertical transmission

Identifiers

PMID28137808
PMCPMC5365725
OpenAlexW2583053072

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.