ReviewHuman reproduction (Oxford, England)2017
Is human fecundity changing? A discussion of research and data gaps precluding us from having an answer.
Review in Human reproduction (Oxford, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- The environmental and occupational influence of pesticides on male fertility: A systematic review of human studies.Andrology · 2022Pooled it
- Persistent organic pollutants and couple fecundability: a systematic review.Human reproduction update · 2021Pooled it
- Endometrial preparation for women undergoing embryo transfer with frozen embryos or embryos derived from donor oocytes.The Cochrane database of systematic reviews · 2020Pooled it
- Exposure to non-persistent chemicals in consumer products and fecundability: a systematic review.Human reproduction update · 2019Pooled it
- Changes in the comprehensive unassisted pregnancy rate as a possible marker of declining human fecundity.Scientific reports · 2025Article
- Impact of night shift work on women's fertility, pregnancy and menopause.Frontiers in sleep · 2025Review
- The Global Decline in Human Fertility: The Post-Transition Trap Hypothesis.Life (Basel, Switzerland) · 2024Review
- Frequency, morbidity and equity - the case for increased research on male fertility.Nature reviews. Urology · 2024Review
- Ambient traffic related air pollution in relation to ovarian reserve and oocyte quality in young, healthy oocyte donors.Environment international · 2024Article
- What is driving the global decline of human fertility? Need for a multidisciplinary approach to the underlying mechanisms.Frontiers in reproductive health · 2024Review
- Events Leading to the Establishment of Pregnancy and Placental Formation: The Need to Fine-Tune the Nomenclature on Pregnancy and Gestation.International journal of molecular sciences · 2023Review
- An Exploratory Analysis of Firefighter Reproduction through Survey Data and Biomonitoring.International journal of environmental research and public health · 2023Article
- Optimizing the "Time to pregnancy" in women with multiple sclerosis: the OPTIMUS Delphi survey.Frontiers in neurology · 2023Article
- The effects of endocrine-disrupting chemicals on ovarian- and ovulation-related fertility outcomes.Molecular reproduction and development · 2022Review
- The changing tide of human fertility.Human reproduction (Oxford, England) · 2022Article
- Human Population Density and Reproductive Health: A Changing World Needs Endocrinology.Endocrinology · 2021Article
- Impaired fecundity as a marker of health and survival: a Danish twin cohort study.Human reproduction (Oxford, England) · 2021Article
- Trends in time-to-pregnancy in the USA: 2002 to 2017.Human reproduction (Oxford, England) · 2021Article
- Length-biased semi-competing risks models for cross-sectional data: an application to current duration of pregnancy attempt data.The annals of applied statistics · 2021Article
- Associations between Disability and Infertility among U.S. Reproductive-Aged Women.International journal of environmental research and public health · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors.
Funding
Abstract
Fecundity, the biologic capacity to reproduce, is essential for the health of individuals and is, therefore, fundamental for understanding human health at the population level. Given the absence of a population (bio)marker, fecundity is assessed indirectly by various individual-based (e.g. semen quality, ovulation) or couple-based (e.g. time-to-pregnancy) endpoints. Population monitoring of fecundity is challenging, and often defaults to relying on rates of births (fertility) or adverse outcomes such as genitourinary malformations and reproductive site cancers. In light of reported declines in semen quality and fertility rates in some global regions among other changes, the question as to whether human fecundity is changing needs investigation. We review existing data and novel methodological approaches aimed at answering this question from a transdisciplinary perspective. The existing literature is insufficient for answering this question; we provide an overview of currently available resources and novel methods suitable for delineating temporal patterns in human fecundity in future research.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.