Evidence map›Paper›PMID 28137612›Full record

ReviewMolecular and cellular endocrinology2017

Nutrition and fasting mimicking diets in the prevention and treatment of autoimmune diseases and immunosenescence.

In Young Choi, Changhan Lee, Valter D Longo

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Molecular and cellular endocrinology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 135 citations in OpenAlex.

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11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

In Young ChoiLongevity Institute, Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA; Department of Microbiology, Immunology, Molecular Genetics, University of California Los Angeles, Los Angeles, CA 90095, USA.
Changhan LeeLongevity Institute, Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA.
Valter D LongoLongevity Institute, Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA; Department of Neuroscience, Dana and David Dornsife College of Letters, Arts and Sciences, University of Southern California, Los Angeles, CA 90089, USA; Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA; IFOM, FIRC Institute of Molecular Oncology, 20139, Milan, Italy. Electronic address: vlongo@usc.edu.
University of Southern California · USHuman Longevity (United States) · US

Funding

Novel Regulators of Aging Metabolism Encoded in the Mitochondrial GenomeR01AG052558 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI LEE, CHANGHAN · 2016 to 2020
$1.8M
NIA NIH HHS R01 AG052558
6 · The paper itself

Abstract

Complex and coordinated signals are necessary to initiate and sustain the activation, proliferation, and differentiation of lymphocytes. These signals, which are known to determine T-cell fate and function, also depend on the metabolic state of the organism. Recent studies indicate that both the type and levels of nutrients can influence the generation, survival and function of lymphocytes and therefore can affect several autoimmune diseases. Here, we review the dysregulation of lymphocytes during autoimmunity and aging, the mechanisms associated with loss of immune function, and how fasting mimicking diets and other dietary interventions affect autoimmunity and immunosenescence.

Indexed as

AgingAnimalsArthritis, RheumatoidAutoimmune DiseasesCaloric RestrictionDiabetes Mellitus, Type 1DietDisease Models, AnimalFastingHumansImmunosenescenceMiceMultiple SclerosisNutritional StatusT-LymphocytesAgingAutoimmune diseasesFastingFasting mimicking dietImmunosenescenceMetabolism

Identifiers

PMID28137612
PMCPMC5862044
OpenAlexW2581841465

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.