Evidence map›Paper›PMID 28137255›Full record

ArticleBMC cancer2017

The Norwegian dietary guidelines and colorectal cancer survival (CRC-NORDIET) study: a food-based multicentre randomized controlled trial.

Hege Berg Henriksen, Hanna Ræder, Siv Kjølsrud Bøhn, Ingvild Paur, Ane Sørlie Kværner, Siv Åshild Billington, Morten Tandberg Eriksen, Gro Wiedsvang, Iris Erlund, Arne Færden and 4 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01570010 (The Norwegian Dietary Guidelines and Colorectal Cancer Survival Study), which is not on this map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01570010 naactive not recruitingnot on this map

The Norwegian Dietary Guidelines and Colorectal Cancer Survival Study: A Food-based Multicentre Randomized Controlled Trial

TypeinterventionalSponsorUniversity of OsloRan2012 to 2040Enrolled503ConditionsColorectal CancerArmsNorwegian food based dietary guidelines
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

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  12. Therapeutic approaches to colorectal cancerFrontiers in microbiology · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Hege Berg HenriksenDepartment of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Hanna RæderDepartment of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Siv Kjølsrud BøhnDepartment of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Ingvild PaurDepartment of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Ane Sørlie KværnerDepartment of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Siv Åshild BillingtonDepartment of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Morten Tandberg EriksenDepartment of Gastroenterological Surgery, Oslo University Hospital, Ullevål, Norway.
Gro WiedsvangDepartment of Gastroenterological Surgery, Oslo University Hospital, Ullevål, Norway.
Iris ErlundNational Institute for Health and Welfare, Helsinki, Finland.
Arne FærdenDepartment of Digestive and Paediatric Surgery, Akershus University Hospital, Lørenskog, Norway.
Marit Bragelien VeierødOslo Centre for Biostatistics and Epidemiology, Department of Biostatistics, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Manuela ZucknickOslo Centre for Biostatistics and Epidemiology, Department of Biostatistics, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Sigbjørn SmelandInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
Rune BlomhoffDepartment of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway. rune.blomhoff@medisin.uio.no.
University of Oslo · NOOslo University Hospital · NOAkershus University Hospital · NOFinnish Institute for Health and Welfare · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundColorectal cancer survivors are not only at risk for recurrent disease but also at increased risk of comorbidities such as other cancers, cardiovascular disease, diabetes, hypertension and functional decline. In this trial, we aim at investigating whether a diet in accordance with the Norwegian food-based dietary guidelines and focusing at dampening inflammation and oxidative stress will improve long-term disease outcomes and survival in colorectal cancer patients. METHODS/

designThis paper presents the study protocol of the Norwegian Dietary Guidelines and Colorectal Cancer Survival study. Men and women aged 50-80 years diagnosed with primary invasive colorectal cancer (Stage I-III) are invited to this randomized controlled, parallel two-arm trial 2-9 months after curative surgery. The intervention group (n = 250) receives an intensive dietary intervention lasting for 12 months and a subsequent maintenance intervention for 14 years. The control group (n = 250) receives no dietary intervention other than standard clinical care. Both groups are offered equal general advice of physical activity. Patients are followed-up at 6 months and 1, 3, 5, 7, 10 and 15 years after baseline. The study center is located at the Department of Nutrition, University of Oslo, and patients are recruited from two hospitals within the South-Eastern Norway Regional Health Authority. Primary outcomes are disease-free survival and overall survival. Secondary outcomes are time to recurrence, cardiovascular disease-free survival, compliance to the dietary recommendations and the effects of the intervention on new comorbidities, intermediate biomarkers, nutrition status, physical activity, physical function and quality of life. DISCUSSION: The current study is designed to gain a better understanding of the role of a healthy diet aimed at dampening inflammation and oxidative stress on long-term disease outcomes and survival in colorectal cancer patients. Since previous research on the role of diet for colorectal cancer survivors is limited, the study may be of great importance for this cancer population.

trial registrationClinicalTrials.gov Identifier: NCT01570010 .

Indexed as

AgedAged, 80 and overColorectal NeoplasmsDisease-Free SurvivalFemaleHumansMaleMiddle AgedMulticenter Studies as TopicNeoplasm Recurrence, LocalNorwayOxidative StressRandomized Controlled Trials as TopicResearch DesignTreatment OutcomeAntioxidant-rich foodsCardiovascular disease-free survivalColorectal cancerComorbidityDisease-free survivalFood-based dietary guidelinesInflammationOverall survivalOxidative stressTime to recurrence

Identifiers

PMID28137255
PMCPMC5282711
OpenAlexW2582262754

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.