Evidence map›Paper›PMID 28135905›Full record

ReviewSmall GTPases2018

New insights into the function of Rab GTPases in the context of exosomal secretion.

Lionel Blanc, Michel Vidal

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Small GTPases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 211 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
211citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

211 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  20. Does extracellular vesicle specificity truly exist?Cell communication and signaling : CCS · 2026
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151 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Lionel Blanca Laboratory of Developmental Erythropoiesis, The Feinstein Institute for Medical Research Hofstra Northwell School of Medicine , Manhasset , NY , USA.ORCID 0000-0002-0185-6260
Michel Vidalb UMR 5235, CNRS, Université Montpellier , cc107, Montpellier , France.

Funding

Critical Regulatory Circuits in Blood FormationR01HL134043 · NHLBI · JACKSON LABORATORY · PI PETERS, LUANNE L · 2016 to 2019
$2.6M
NHLBI NIH HHS R01 HL134043
6 · The paper itself

Abstract

In the last two decades, extracellular vesicle-mediated communication between cells has become a major field in cell biology. However, the function of extracellular vesicles is far from clear, especially due to the disparity of released vesicles by cells. Basically, one must consider vesicles budding from the cell plasma membrane (ectosomes) and vesicles released upon fusion of an endosomal multivesicular compartment (exosomes). Moreover, even for exosomes, we report and discuss here the possibility that different routes regulated by specific Rab GTPases might produce exosomes having various biologic functions.

Indexed as

ExosomesHumansrab GTP-Binding Proteinsrab GTP-Binding ProteinscommunicationdisposalexosomesRab GTPases

Identifiers

PMID28135905
PMCPMC5902209

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.