ArticleNeurorehabilitation and neural repair2017
Mapping Common Aphasia Assessments to Underlying Cognitive Processes and Their Neural Substrates.
Article in Neurorehabilitation and neural repair, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 1 of them a synthesis that pooled it.
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Who cites it
67 citing papers in PubMed, 1 synthesis or guideline pooled it, 114 citations in OpenAlex.
- Multiple dimensions underlying the functional organization of the language network.NeuroImage · 2021Pooled it
- Right Hemisphere Functional Connectivity Increases in Proportion to Left Hemisphere Lesion Size, but Not Within the Language Network.Human brain mapping · 2026Observational
- Causal dependencies between frontal and temporal lobe regions underlying word search and retrieval.bioRxiv : the preprint server for biology · 2026Article
- A Rapid fMRI Paradigm for Localisation of the Language Network.The European journal of neuroscience · 2026Article
- Visual processing of manipulable objects in the ventral stream is modulated by parietal action systems.Brain communications · 2026Article
- The neural correlates of novel versus familiar metaphors in healthy young adults: A functional near-infrared spectroscopy study.bioRxiv : the preprint server for biology · 2025Article
- Using unsupervised dimensionality reduction to identify lesion patterns predictive of post-stroke aphasia severity.Cortex; a journal devoted to the study of the nervous system and behavior · 2025Article
- Causal Lesion Evidence for Two Motor Speech Coordination Networks in the Brain.bioRxiv : the preprint server for biology · 2025Article
- Non-Verbal Working Memory in Post-Stroke Motor Aphasia: A Pilot Study Using the Tactual Span.Neurology international · 2025Article
- Exploring benefits of speech and language therapy interventions for post-stroke aphasia rehabilitation: A qualitative study.Heliyon · 2025Article
- Lesion-Induced Changes to the Network Controllability of the Right Pars Triangularis in Aphasia.Neurobiology of language (Cambridge, Mass.) · 2025Article
- The role of cognitive control and naming in aphasia.Biologia futura · 2024Article
- Mechanisms and neuroanatomy of response selection in tool and non-tool action tasks: Evidence from left-hemisphere stroke.Cortex; a journal devoted to the study of the nervous system and behavior · 2023Article
- Defining aphasia: Content analysis of six aphasia diagnostic batteries.Cortex; a journal devoted to the study of the nervous system and behavior · 2023Article
- Three-Dimensional Speech Profiles in Stroke Aphasia and Apraxia of Speech.American journal of speech-language pathology · 2023Article
- Benefit of visual speech information for word comprehension in post-stroke aphasia.Cortex; a journal devoted to the study of the nervous system and behavior · 2023Article
- Using in vivo functional and structural connectivity to predict chronic stroke aphasia deficits.Brain : a journal of neurology · 2023Article
- Shared and distinct routes in speech and gesture imitation: Evidence from stroke.Cortex; a journal devoted to the study of the nervous system and behavior · 2023Article
- Neuroanatomy of post-stroke depression: the association between symptom clusters and lesion location.Brain communications · 2023Article
- Mapping correlated neurological deficits after stroke to distributed brain networks.Brain structure & function · 2022Review
7 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundUnderstanding the relationships between clinical tests, the processes they measure, and the brain networks underlying them, is critical in order for clinicians to move beyond aphasia syndrome classification toward specification of individual language process impairments.
objectiveTo understand the cognitive, language, and neuroanatomical factors underlying scores of commonly used aphasia tests.
methodsTwenty-five behavioral tests were administered to a group of 38 chronic left hemisphere stroke survivors and a high-resolution magnetic resonance image was obtained. Test scores were entered into a principal components analysis to extract the latent variables (factors) measured by the tests. Multivariate lesion-symptom mapping was used to localize lesions associated with the factor scores.
resultsThe principal components analysis yielded 4 dissociable factors, which we labeled Word Finding/Fluency, Comprehension, Phonology/Working Memory Capacity, and Executive Function. While many tests loaded onto the factors in predictable ways, some relied heavily on factors not commonly associated with the tests. Lesion symptom mapping demonstrated discrete brain structures associated with each factor, including frontal, temporal, and parietal areas extending beyond the classical language network. Specific functions mapped onto brain anatomy largely in correspondence with modern neural models of language processing.
conclusionsAn extensive clinical aphasia assessment identifies 4 independent language functions, relying on discrete parts of the left middle cerebral artery territory. A better understanding of the processes underlying cognitive tests and the link between lesion and behavior may lead to improved aphasia diagnosis, and may yield treatments better targeted to an individual's specific pattern of deficits and preserved abilities.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.