ArticleThe American journal of psychiatry2017
Multimodal Neuroimaging of Frontolimbic Structure and Function Associated With Suicide Attempts in Adolescents and Young Adults With Bipolar Disorder.
Article in The American journal of psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 115 papers, 2 of them syntheses that pooled it.
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Who cites it
115 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Structural connectivity abnormalities in suicidal thoughts and behaviours: a meta-analysis.Translational psychiatry · 2025Pooled it
- A Systematic Review of MRI Studies and the "Emotional paiN and social Disconnect (END)" Brain Model of Suicidal Behavior in Youth.Behavioural neurology · 2023Pooled it
- Dual-Site aiTBS for Suicidal Ideation in Adolescents With Major Depressive Disorder: A Randomized Clinical Trial.JAMA network open · 2026Trial
- Chronotherapeutic intervention targeting emotion regulation brain circuitry, symptoms, and suicide risk in adolescents and young adults with bipolar disorder: a pilot randomised trial.BMJ mental health · 2025Trial
- Efficacy and Safety of Transcranial Direct Current Stimulation as an Add-On Trial Treatment for Acute Bipolar Depression Patients With Suicidal Ideation.CNS neuroscience & therapeutics · 2024Trial
- Association of Polygenic Risk Score for Suicidal Behavior With Ventral Prefrontal Morphology in Bipolar Disorder.Bipolar disorders · 2026Article
- Suicide attempts, white matter microstructure, and cognitive function in schizophrenia.European archives of psychiatry and clinical neuroscience · 2026Article
- Cortical Thickness in Middle and Older Aged Adults With Bipolar Disorder Across Six International Sites.Bipolar disorders · 2026Article
- Characteristics of non-suicidal self-injury and its associations with thyroid and sex hormones in adolescents with major depressive disorder and bipolar disorder.BMC psychiatry · 2026Article
- Longitudinal changes in amygdala-supplementary motor area connectivity and their association with recurrent self-harm in adolescents with mood disorders.BMC psychiatry · 2026Article
- Biological Risk Factors for Suicidal Behavior in Children and Adolescents: A Narrative Review.Children (Basel, Switzerland) · 2026Review
- Factors influencing suicidal ideation in Chinese adolescents with first-episode depressive disorder: a cross-sectional study.BMC psychology · 2026Article
- Potential predictors of future suicide attempts in adolescents assigned female at birth.Journal of affective disorders · 2026Article
- Generalizable structure-function covariation predictive of antidepressant response revealed by target-oriented multimodal fusion.Nature. Mental health · 2026Article
- Cognitive reappraisal mediated the relationship between childhood emotional neglect and suicidality in depressed adolescents and young adults with NSSI behavior.Frontiers in psychiatry · 2026Article
- Exploring the neurobiological markers of suicidal behaviors in pediatric population: a narrative review.Frontiers in pediatrics · 2026Review
- Understanding the emergence of suicidal thoughts and behaviors in adolescence from a brain and behavioral developmental perspective.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Transdiagnostic alterations in white matter microstructure associated with suicidal thoughts and behaviours in the ENIGMA Suicidal Thoughts and Behaviours consortium.Translational psychiatry · 2025Article
- The Chinese version of the Self-Injurious thoughts and behaviors Interview-Revised (C-SITBI-R): assessing NSSI and suicidal behaviors among adolescents in clinical settings.BMC psychiatry · 2025Article
- An observational study on gray matter volume and white matter integrity in suicide attempters with bipolar I disorder.Indian journal of psychiatry · 2025Article
55 more citing papers are in PubMed but not listed here.
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Authors and funding
17 authors.
Funding
Abstract
objectiveBipolar disorder is associated with high risk for suicidal behavior that often develops in adolescence and young adulthood. Elucidation of involved neural systems is critical for prevention. This study of adolescents and young adults with bipolar disorder with and without a history of suicide attempts combines structural, diffusion tensor, and functional MR imaging methods to investigate implicated abnormalities in the morphology and structural and functional connectivity within frontolimbic systems.
methodThe study had 26 participants with bipolar disorder who had a prior suicide attempt (the attempter group) and 42 participants with bipolar disorder without a suicide attempt (the nonattempter group). Regional gray matter volume, white matter integrity, and functional connectivity during processing of emotional stimuli were compared between groups, and differences were explored for relationships between imaging modalities and associations with suicide-related symptoms and behaviors.
resultsCompared with the nonattempter group, the attempter group showed significant reductions in gray matter volume in the orbitofrontal cortex, hippocampus, and cerebellum; white matter integrity in the uncinate fasciculus, ventral frontal, and right cerebellum regions; and amygdala functional connectivity to the left ventral and right rostral prefrontal cortex. In exploratory analyses, among attempters, there was a significant negative correlation between right rostral prefrontal connectivity and suicidal ideation and between left ventral prefrontal connectivity and attempt lethality.
conclusionsAdolescent and young adult suicide attempters with bipolar disorder demonstrate less gray matter volume and decreased structural and functional connectivity in a ventral frontolimbic neural system subserving emotion regulation. Among attempters, reductions in amygdala-prefrontal functional connectivity may be associated with severity of suicidal ideation and attempt lethality.
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