Evidence map›Paper›PMID 28135843›Full record

Trial reportThe American journal of psychiatry2017

A Randomized Controlled Trial of Ethyl Glucuronide-Based Contingency Management for Outpatients With Co-Occurring Alcohol Use Disorders and Serious Mental Illness.

Michael G McDonell, Emily Leickly, Sterling McPherson, Jordan Skalisky, Debra Srebnik, Frank Angelo, Roger Vilardaga, Jenny R Nepom, John M Roll, Richard K Ries

Erratum issuedOpen access · bronzeAbstract readComparative StudyMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The American journal of psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 53 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 3 pooled it
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 3 syntheses or guidelines pooled it, 81 citations in OpenAlex.

  1. Pooled it
  2. The dissemination and implementation of contingency management for substance use disorders: A systematic review.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2020
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Michael G McDonellFrom the Initiative for Research and Education to Advance Community Health, Washington State University, Spokane, Wash.; the Elson S. Floyd College of Medicine, Washington State University, Spokane, Wash.; the Program for Excellence in Addiction Research, Washington State University, Spokane, Wash.; the Providence Medical Research Center, Providence Health Care, Spokane, Wash.; the Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Wash.; and the School of Public Health, University of Washington, Seattle, Wash.
Emily LeicklyFrom the Initiative for Research and Education to Advance Community Health, Washington State University, Spokane, Wash.; the Elson S. Floyd College of Medicine, Washington State University, Spokane, Wash.; the Program for Excellence in Addiction Research, Washington State University, Spokane, Wash.; the Providence Medical Research Center, Providence Health Care, Spokane, Wash.; the Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Wash.; and the School of Public Health, University of Washington, Seattle, Wash.
Sterling McPhersonFrom the Initiative for Research and Education to Advance Community Health, Washington State University, Spokane, Wash.; the Elson S. Floyd College of Medicine, Washington State University, Spokane, Wash.; the Program for Excellence in Addiction Research, Washington State University, Spokane, Wash.; the Providence Medical Research Center, Providence Health Care, Spokane, Wash.; the Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Wash.; and the School of Public Health, University of Washington, Seattle, Wash.
Jordan SkaliskyFrom the Initiative for Research and Education to Advance Community Health, Washington State University, Spokane, Wash.; the Elson S. Floyd College of Medicine, Washington State University, Spokane, Wash.; the Program for Excellence in Addiction Research, Washington State University, Spokane, Wash.; the Providence Medical Research Center, Providence Health Care, Spokane, Wash.; the Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Wash.; and the School of Public Health, University of Washington, Seattle, Wash.
Debra SrebnikFrom the Initiative for Research and Education to Advance Community Health, Washington State University, Spokane, Wash.; the Elson S. Floyd College of Medicine, Washington State University, Spokane, Wash.; the Program for Excellence in Addiction Research, Washington State University, Spokane, Wash.; the Providence Medical Research Center, Providence Health Care, Spokane, Wash.; the Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Wash.; and the School of Public Health, University of Washington, Seattle, Wash.
Frank AngeloFrom the Initiative for Research and Education to Advance Community Health, Washington State University, Spokane, Wash.; the Elson S. Floyd College of Medicine, Washington State University, Spokane, Wash.; the Program for Excellence in Addiction Research, Washington State University, Spokane, Wash.; the Providence Medical Research Center, Providence Health Care, Spokane, Wash.; the Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Wash.; and the School of Public Health, University of Washington, Seattle, Wash.
Roger VilardagaFrom the Initiative for Research and Education to Advance Community Health, Washington State University, Spokane, Wash.; the Elson S. Floyd College of Medicine, Washington State University, Spokane, Wash.; the Program for Excellence in Addiction Research, Washington State University, Spokane, Wash.; the Providence Medical Research Center, Providence Health Care, Spokane, Wash.; the Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Wash.; and the School of Public Health, University of Washington, Seattle, Wash.
Jenny R NepomFrom the Initiative for Research and Education to Advance Community Health, Washington State University, Spokane, Wash.; the Elson S. Floyd College of Medicine, Washington State University, Spokane, Wash.; the Program for Excellence in Addiction Research, Washington State University, Spokane, Wash.; the Providence Medical Research Center, Providence Health Care, Spokane, Wash.; the Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Wash.; and the School of Public Health, University of Washington, Seattle, Wash.
John M RollFrom the Initiative for Research and Education to Advance Community Health, Washington State University, Spokane, Wash.; the Elson S. Floyd College of Medicine, Washington State University, Spokane, Wash.; the Program for Excellence in Addiction Research, Washington State University, Spokane, Wash.; the Providence Medical Research Center, Providence Health Care, Spokane, Wash.; the Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Wash.; and the School of Public Health, University of Washington, Seattle, Wash.
Richard K RiesFrom the Initiative for Research and Education to Advance Community Health, Washington State University, Spokane, Wash.; the Elson S. Floyd College of Medicine, Washington State University, Spokane, Wash.; the Program for Excellence in Addiction Research, Washington State University, Spokane, Wash.; the Providence Medical Research Center, Providence Health Care, Spokane, Wash.; the Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Wash.; and the School of Public Health, University of Washington, Seattle, Wash.
Washington State University Spokane · US

Funding

Novel EtG BasedContingency Management for Alcohol in the Severely Mentally IllR01AA020248 · NIAAA · WASHINGTON STATE UNIVERSITY · PI MCDONELL, MICHAEL G · 2012 to 2021
$4.6M
Innovative Smartphone Application for Quitting Smoking among Seriously Mentally IIIR00DA037276 · NIDA · DUKE UNIVERSITY · PI VILARDAGA, ROGER · 2016 to 2018
$747k
NIAAA NIH HHS R01 AA020248NIDA NIH HHS R00 DA037276
6 · The paper itself

Abstract

objectiveThe authors examined whether a contingency management intervention using the ethyl glucuronide (EtG) alcohol biomarker resulted in increased alcohol abstinence in outpatients with co-occurring serious mental illnesses. Secondary objectives were to determine whether contingency management was associated with changes in heavy drinking, treatment attendance, drug use, cigarette smoking, psychiatric symptoms, and HIV-risk behavior.

methodSeventy-nine (37% female, 44% nonwhite) outpatients with serious mental illness and alcohol dependence receiving treatment as usual completed a 4-week observation period and were randomly assigned to 12 weeks of contingency management for EtG-negative urine samples and addiction treatment attendance, or reinforcement only for study participation. Contingency management included the variable magnitude of reinforcement "prize draw" procedure contingent on EtG-negative samples (<150 ng/mL) three times a week and weekly gift cards for outpatient treatment attendance. Urine EtG, drug test, and self-report outcomes were assessed during the 12-week intervention and 3-month follow-up periods.

resultsContingency management participants were 3.1 times (95% CI=2.2-4.5) more likely to submit an EtG-negative urine test during the 12-week intervention period, attaining nearly 1.5 weeks of additional alcohol abstinence compared with controls. Contingency management participants had significantly lower mean EtG levels, reported less drinking and fewer heavy drinking episodes, and were more likely to submit stimulant-negative urine and smoking-negative breath samples, compared with controls. Differences in self-reported alcohol use were maintained at the 3-month follow-up.

conclusionsThis is the first randomized trial utilizing an accurate and validated biomarker (EtG) to demonstrate the efficacy of contingency management for alcohol dependence in outpatients with serious mental illness.

Indexed as

AlcoholismGlucuronatesMental DisordersToken EconomyAdultAmbulatory CareComorbidityDiagnosis, Dual (Psychiatry)FemaleFollow-Up StudiesHumansMaleMiddle AgedPatient Complianceethyl glucuronideGlucuronatesAlcohol AbuseBiological MarkersChronic Psychiatric Illness

Identifiers

PMID28135843
PMCPMC5378651
OpenAlexW2584453464

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.