Evidence map›Paper›PMID 28135689›Full record

ArticleJournal of affective disorders2017

Test-retest reliability and validity of a frustration paradigm and irritability measures.

Wan-Ling Tseng, Elizabeth Moroney, Laura Machlin, Roxann Roberson-Nay, John M Hettema, Dever Carney, Joel Stoddard, Kenneth A Towbin, Daniel S Pine, Ellen Leibenluft and 1 more

Registry-linked trialOpen access · greenAbstract readValidation Study
In one paragraph

Article in Journal of affective disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04051320 (Characterizing the Neural Substrates of Irritability in Women), which is not on this map. Cited by 38 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
4.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04051320 phase2completednot on this mapstarted 2020, after this paper: background citation

Characterizing the Neural Substrates of Irritability in Women: an Experimental Neuroendocrine Model

TypeinterventionalSponsorUniversity of North Carolina, Chapel HillRan2020 to 2022Enrolled23ConditionsPerinatal Depression, Post Partum Depression, Depression, Postpartum, DepressionArmsLeuprolide Acetate 3.75 MG/ML, Estradiol 2 Mg tablet, Micronized progesterone
3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.

  1. Evidence Base Update on the Assessment of Irritability, Anger, and Aggression in Youth.Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53
    Pooled it
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  4. Bidirectional association between irritability and executive function in youth from late childhood to early adolescence: Between- and within-person effects.Journal of research on adolescence : the official journal of the Society for Research on Adolescence · 2026
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  18. Network analysis of ecological momentary assessment identifies frustration as a central node in irritability.Journal of child psychology and psychiatry, and allied disciplines · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Wan-Ling TsengEmotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA. Electronic address: wan-ling.tseng@nih.gov.
Elizabeth MoroneyEmotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.
Laura MachlinEmotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.
Roxann Roberson-NayDepartment of Psychiatry and the Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.
John M HettemaDepartment of Psychiatry and the Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.
Dever CarneyDepartment of Psychiatry and the Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.
Joel StoddardEmotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.
Kenneth A TowbinEmotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.
Daniel S PineEmotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.
Ellen LeibenluftEmotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.
Melissa A BrotmanEmotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.
National Institutes of Health · USNational Institute of Mental Health · USVirginia Commonwealth University · US

Funding

The Pathophysiology and Treatment Of Children With Severe Mood DysregulationZIAMH002786 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI LEIBENLUFT, ELLEN · 2009 to 2023
$34.0M
Genetic Contributions of Negative Valence Systems to Internalizing PathwaysR01MH101518 · NIMH · VIRGINIA COMMONWEALTH UNIVERSITY · PI ROBERSON-NAY, ROXANN · 2013 to 2016
$2.3M
A Twin Study of Negative Valence Emotional ConstructsR01MH098055 · NIMH · VIRGINIA COMMONWEALTH UNIVERSITY · PI HETTEMA, JOHN M · 2012 to 2014
$1.6M
NIMH NIH HHS R01 MH098055NIMH NIH HHS R01 MH101518
6 · The paper itself

Abstract

backgroundData on the reliability and validity of assessments for irritability, particularly behavioral paradigms, are limited. This study examined the test-retest reliability and validity of a frustration paradigm (the Affective Posner 2 task) and two irritability measures [the Affective Reactivity Index (ARI) and Child Behavior Checklist (CBCL) irritability].

methodsParticipants were 109 youth from a general population sample of twins (aged 9-14 years). Participants completed two visits that were 2-4 weeks apart. At both visits, participants completed the Affective Posner 2 task and self-reported their irritability using the ARI. Parents reported their child's irritability using the ARI and completed the CBCL.

resultsThe Affective Posner 2 task demonstrated good test-retest reliability, with intraclass correlations (ICCs) ranging from .44 to .78. The task effectively evoked negative affect (frustration and unhappiness) at both test and retest, demonstrating its construct validity. Moreover, self-rated frustration and unhappiness during the frustration components of the task correlated positively with self-reported but not parent-reported irritability, providing modest support for convergent validity. Parent- and child-reports of the ARI and parent-reports of the CBCL irritability measure showed excellent test-retest reliability, with ICCs ranging from .88 to .90. LIMITATIONS: The sample consists of mostly twins aged 9-14 years from the communities. Thus, results may not generalize to non-twin samples or clinical samples outside of this age range.

conclusionsThe Affective Posner 2 paradigm and the ARI and CBCL irritability scales may be useful tools for longitudinal or treatment research on irritability.

Indexed as

FrustrationIrritable MoodPersonality TestsAdolescentChecklistChildFemaleHumansMaleParentsReproducibility of ResultsSelf ReportSurveys and QuestionnairesFrustrationIrritabilityParent-child agreementTest-retest reliabilityValidity

Identifiers

PMID28135689
PMCPMC8049456
OpenAlexW2582174699

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.