ArticleNature genetics2017
Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk.
Erratum issuedOpen access · hybridAbstract read
In one paragraph
Article in Nature genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 314 papers, 17 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
314citing papers in PubMed, 17 pooled it
65.0field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
314 citing papers in PubMed, 17 syntheses or guidelines pooled it, 584 citations in OpenAlex.
- Accelerated epigenetic age in hypertension: a systematic review and meta-analysis.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Pooled it
- Genome-wide association study provides novel insight into the genetic architecture of severe obesity.PLoS genetics · 2025Pooled it
- The Role of Diet in the Prevention of Hypertension and Management of Blood Pressure: An Umbrella Review of Meta-Analyses of Interventional and Observational Studies.Advances in nutrition (Bethesda, Md.) · 2024Pooled it
- Genome-wide association study meta-analysis of blood pressure traits and hypertension in sub-Saharan African populations: an AWI-Gen study.Nature communications · 2023Pooled it
- Meta-Analysis and Multivariate GWAS Analyses in 80,950 Individuals of African Ancestry Identify Novel Variants Associated with Blood Pressure Traits.International journal of molecular sciences · 2023Pooled it
- Genetic and clinical determinants of abdominal aortic diameter: genome-wide association studies, exome array data and Mendelian randomization study.Human molecular genetics · 2022Pooled it
- Insights From a Large-Scale Whole-Genome Sequencing Study of Systolic Blood Pressure, Diastolic Blood Pressure, and Hypertension.Hypertension (Dallas, Tex. : 1979) · 2022Pooled it
- High Blood Pressure and Intraocular Pressure: A Mendelian Randomization Study.Investigative ophthalmology & visual science · 2022Pooled it
- Genome-wide pleiotropy analysis identifies novel blood pressure variants and improves its polygenic risk scores.Genetic epidemiology · 2022Pooled it
- First genome-wide association study investigating blood pressure and renal traits in domestic cats.Scientific reports · 2022Pooled it
- Meta-analysis of epigenome-wide association studies of carotid intima-media thickness.European journal of epidemiology · 2021Pooled it
- Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals.Nature genetics · 2020Pooled it
- Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci.Molecular psychiatry · 2020Pooled it
- Blood DNA methylation sites predict death risk in a longitudinal study of 12, 300 individuals.Aging · 2020Pooled it
- Genome-wide meta-analysis of variant-by-diuretic interactions as modulators of lipid traits in persons of European and African ancestry.The pharmacogenomics journal · 2020Pooled it
- Genome-wide association identifies seven loci for pelvic organ prolapse in Iceland and the UK Biobank.Communications biology · 2020Pooled it
- Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure.Nature communications · 2020Pooled it
- Sodium Sensitivity, Sodium Resistance, and Incidence of Hypertension: A Longitudinal Follow-Up Study of Dietary Sodium Intervention.Hypertension (Dallas, Tex. : 1979) · 2021Trial
- Dementia risk across distinct metabolic profiles in the UK Biobank.GeroScience · 2026Article
- Identifying sex-specific genetic effects across 733 traits in UK biobank.BMC genomics · 2026Article
254 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
70 authors at 20 institutions in 11 countries.
Helen R WarrenWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Evangelos EvangelouDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.ORCID http://orcid.org/0000-0002-5488-2999
Claudia P CabreraWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
He GaoDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
Meixia RenWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Borbala MifsudWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Ioanna NtallaWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Praveen SurendranCardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Chunyu LiuPopulation Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
James P CookDepartment of Biostatistics, University of Liverpool, Liverpool, UK.
Aldi T KrajaDivision of Statistical Genomics, Department of Genetics and Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, Missouri, USA.
Fotios DrenosMRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, UK.
Marie LohDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
Niek VerweijUniversity of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, the Netherlands.
Jonathan MartenMRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Ibrahim KaramanDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.ORCID http://orcid.org/0000-0001-9341-8155
Marcelo P Segura LepeDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
Paul F O'ReillyInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Joanne KnightData Science Institute, Lancester University, Lancaster, UK.
Harold SniederUniversity of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, the Netherlands.
Norihiro KatoDepartment of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
Jiang HeDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, USA.
E Shyong TaiSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore.
M Abdullah SaidUniversity of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, the Netherlands.
David PorteousCentre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0003-1249-6106
Maris AlverEstonian Genome Center, University of Tartu, Tartu, Estonia.
Neil PoulterImperial Clinical Trials Unit, School of Public Health, Imperial College London, London, UK.
Martin FarrallDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Ron T GansevoortUniversity of Groningen, University Medical Center Groningen, Department of Nephrology, Groningen, the Netherlands.
Sandosh PadmanabhanInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
Reedik MägiEstonian Genome Center, University of Tartu, Tartu, Estonia.
Alice StantonMolecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland.ORCID http://orcid.org/0000-0002-4961-165X
John ConnellNinewells Hospital and Medical School, University of Dundee, Dundee, UK.
Stephan J L BakkerUniversity of Groningen, University Medical Center Groningen, Department of Internal Medicine, Groningen, the Netherlands.
Andres MetspaluEstonian Genome Center, University of Tartu, Tartu, Estonia.
Denis C ShieldsSchool of Medicine, Conway Institute, University College Dublin, Dublin, Ireland.
Simon ThomNational Heart and Lung Institute, Imperial College London, London, UK.ORCID http://orcid.org/0000-0002-3020-1351
Morris BrownWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Peter SeverNational Heart and Lung Institute, Imperial College London, London, UK.
Tõnu EskoProgram in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.
Caroline HaywardMRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Pim van der HarstUniversity of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, the Netherlands.
Danish SaleheenDepartment of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Rajiv ChowdhuryCardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
John C ChambersDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
Daniel I ChasmanDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Aravinda ChakravartiCenter for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Christopher Newton-ChehProgram in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.
Cecilia M LindgrenProgram in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.
Daniel LevyPopulation Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
Jaspal S KoonerImperial College Healthcare NHS Trust, London, UK.
Bernard KeavneyDivision of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.ORCID http://orcid.org/0000-0001-9573-0812
Maciej TomaszewskiDivision of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Nilesh J SamaniDepartment of Cardiovascular Sciences, University of Leicester, BHF Cardiovascular Research Centre, Glenfield Hospital, Leicester, UK.
Joanna M M HowsonCardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Martin D TobinDepartment of Health Sciences, University of Leicester, Leicester, UK.
Patricia B MunroeWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Georg B EhretCenter for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID http://orcid.org/0000-0002-5730-0675
Louise V WainDepartment of Health Sciences, University of Leicester, Leicester, UK.ORCID http://orcid.org/0000-0003-4951-1867
International Consortium of Blood Pressure (ICBP) 1000G Analyses
BIOS Consortium
Lifelines Cohort Study
Understanding Society Scientific group
CHD Exome+ Consortium
ExomeBP Consortium
T2D-GENES Consortium
GoT2DGenes Consortium
Cohorts for Heart and Ageing Research in Genome Epidemiology (CHARGE) BP Exome Consortium
International Genomics of Blood Pressure (iGEN-BP) Consortium
UK Biobank CardioMetabolic Consortium BP working group
Queen Mary University of London · GBImperial College London · GBBroad Institute · USUniversity Medical Center Groningen · NLUniversity of Leicester · GBImperial College Healthcare NHS Trust · GBInstitute of Genetics and Cancer · GBJohns Hopkins University · USUniversity of Cambridge · GBUniversity of Tartu · EEManchester Academic Health Science Centre · GBBrigham and Women's Hospital · USCentre for Human Genetics · GBKing's College London · GBLancaster University · GBNational Institutes of Health · USRoyal College of Surgeons in Ireland · IEUniversity College Dublin · IEUniversity of Dundee · GBUniversity of Glasgow · GB
Funding
Genome-Wide Association Analysis in Essential Hypertension (FEHGAS study)R01HL086694 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ARAVINDA CHAKRAVARTI · 2007 to 2026
$21.2MGenomics of blood pressure-induced target organ damageR01HL128782 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CHAKRAVARTI, ARAVINDA · 2015 to 2018
$7.8MGenetics of Cardiotoxic Drug Response to Psychiatric TherapyR01HL124262 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI NEWTON-CHEH, CHRISTOPHER HOLMES, PERLIS, ROY H. · 2015 to 2018
$2.7MPhysiologic Profiling of sGC Genetic VariantsR01HL113933 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI NEWTON-CHEH, CHRISTOPHER HOLMES · 2013 to 2016
$2.3MBiotechnology and Biological Sciences Research Council BB/F019394/1British Heart Foundation PG/16/49/32176British Heart Foundation RG/08/014/24067British Heart Foundation RG/15/12/31616British Heart Foundation SP/13/2/30111Chief Scientist Office CZD/16/6/4European Research Council 268834Medical Research Council G0600237Medical Research Council G0800270Medical Research Council MC_PC_U127561128Medical Research Council MC_QA137853Medical Research Council MC_UU_12013/3Medical Research Council MC_UU_12015/1Medical Research Council MR/K006584/1Medical Research Council MR/K026992/1Medical Research Council MR/L003120/1Medical Research Council MR/L01341X/1Medical Research Council MR/L016311/1Medical Research Council MR/L01632X/1Medical Research Council MR/N015746/1NHLBI NIH HHS R01 HL086694NHLBI NIH HHS R01 HL113933NHLBI NIH HHS R01 HL124262NHLBI NIH HHS R01 HL128782Wellcome Trust
Abstract
Elevated blood pressure is the leading heritable risk factor for cardiovascular disease worldwide. We report genetic association of blood pressure (systolic, diastolic, pulse pressure) among UK Biobank participants of European ancestry with independent replication in other cohorts, and robust validation of 107 independent loci. We also identify new independent variants at 11 previously reported blood pressure loci. In combination with results from a range of in silico functional analyses and wet bench experiments, our findings highlight new biological pathways for blood pressure regulation enriched for genes expressed in vascular tissues and identify potential therapeutic targets for hypertension. Results from genetic risk score models raise the possibility of a precision medicine approach through early lifestyle intervention to offset the impact of blood pressure-raising genetic variants on future cardiovascular disease risk.
Indexed as
AdultBlood PressureCardiovascular DiseasesFemaleGenetic LociGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansHypertensionMaleMiddle AgedPolymorphism, Single NucleotideRisk FactorsWhite People
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.