ArticleMicrocirculation (New York, N.Y. : 1994)2017
A conceptual framework for predicting and addressing the consequences of disease-related microvascular dysfunction.
Article in Microcirculation (New York, N.Y. : 1994), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 18 citations in OpenAlex.
- Supplemental Oxygen Improves In Vivo Mitochondrial Oxidative Phosphorylation Flux in Sedentary Obese Adults With Type 2 Diabetes.Diabetes · 2018Trial
- Eugene M Renkin. His Many Contributions to Microvascular Research With Examples of How They Inform Current Investigations of Microvascular Dysfunction.Microcirculation (New York, N.Y. : 1994) · 2025Review
- Association Between Microvascular Disease and Cardiorespiratory Fitness Among Adults With Type 2 Diabetes.Diabetes care · 2024Article
- Capillary Endothelial Insulin Transport: The Rate-limiting Step for Insulin-stimulated Glucose Uptake.Endocrinology · 2022Review
- A novel vascular health index: Using data analytics and population health to facilitate mechanistic modeling of microvascular status.Frontiers in physiology · 2022Article
- Mechanistic Causes of Reduced Cardiorespiratory Fitness in Type 2 Diabetes.Journal of the Endocrine Society · 2020Review
- Perfusion controls muscle glucose uptake by altering the rate of glucose dispersion in vivo.American journal of physiology. Endocrinology and metabolism · 2019Article
- Rapid changes in the microvascular circulation of skeletal muscle impair insulin delivery during sepsis.American journal of physiology. Endocrinology and metabolism · 2019Article
- Does reduced oxygen delivery cause lactic acidosis in falciparum malaria? An observational study.Malaria journal · 2019Observational
- Automated quantification of microvascular perfusion.Microcirculation (New York, N.Y. : 1994) · 2018Article
- Exercise intolerance in Type 2 diabetes: is there a cardiovascular contribution?Journal of applied physiology (Bethesda, Md. : 1985) · 2018Review
- Beneficial Pleiotropic Antidepressive Effects of Cardiovascular Disease Risk Factor Interventions in the Metabolic Syndrome.Journal of the American Heart Association · 2018Article
- Mechanisms of Aerobic Exercise Impairment in Diabetes: A Narrative Review.Frontiers in endocrinology · 2018Review
- Investigation of microvascular morphological measures for skeletal muscle tissue oxygenation by image-based modelling in three dimensions.Journal of the Royal Society, Interface · 2017Article
- Dissociation of local and global skeletal muscle oxygen transport metrics in type 2 diabetes.Journal of diabetes and its complications · 2017Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
objectiveA growing body of evidence indicates that impaired microvascular perfusion plays a pathological role in a number of diseases. This manuscript aims to better define which aspects of microvascular perfusion are important, what mass transport processes (eg, insulin action, tissue oxygenation) may be impacted, and what therapies might reverse these pathologies.
methodsWe derive a theory of microvascular perfusion and solute flux drawing from established relationships in mass transport and anatomy. We then apply this theory to predict relationships between microvascular perfusion parameters and microvascular solute flux.
resultsFor convection-limited exchange processes (eg, pulmonary oxygen uptake), our model predicts that bulk blood flow is of primary importance. For diffusion-limited exchange processes (eg, insulin action), our model predicts that perfused capillary density is of primary importance. For convection/diffusion co-limited exchange processes (eg, tissue oxygenation), our model predicts that various microvascular perfusion parameters interact in a complex, context-specific manner. We further show that our model can predict established mass transport defects in disease (eg, insulin resistance in diabetes).
conclusionsThe contributions of microvascular perfusion parameters to tissue-level solute flux can be described using a minimal mathematical model. Our results hold promise for informing therapeutic interventions targeting microvascular perfusion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.