ReviewComprehensive Physiology2016
Neuropeptide Regulation of Social Attachment: The Prairie Vole Model.
Review in Comprehensive Physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
37 citing papers in PubMed, 48 citations in OpenAlex.
- Role of afterplay in female sexual satisfaction in heterosexual relationship: A prospective randomized two arm study.International journal of impotence research · 2026Article
- An epigenetic framework for understanding contextual influences on neural and socio-emotional development: Narrative review and case-study of the oxytocin receptor.Developmental cognitive neuroscience · 2026Review
- A Demographic History of a Prairie Vole (Microtus ochrogaster) Breeding Colony (2004-2020).Journal of the American Association for Laboratory Animal Science : JAALAS · 2026Article
- A Demographic History of a Prairie Vole (bioRxiv : the preprint server for biology · 2026Article
- The impact of the early environment on oxytocin receptor epigenetics and potential therapeutic implications.Pediatric research · 2025Review
- The deletion of the arginine vasopressin 1a receptor impairs sexual and maternal behavior.Frontiers in endocrinology · 2025Article
- Six types of loves differentially recruit reward and social cognition brain areas.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Association between RMTg Neuropeptide Genes and Negative Effect during Alcohol Withdrawal in Mice.International journal of molecular sciences · 2024Article
- Maternal oxytocin treatment at birth increases epigenetic age in male offspring.Developmental psychobiology · 2024Article
- A test of the social behavior network reveals differential patterns of neural responses to social novelty in bonded, but not non-bonded, male prairie voles.Hormones and behavior · 2023Article
- Transcriptional diversity of the oxytocin receptor in prairie voles: mechanistic implications for behavioral neuroscience and maternal physiology.Frontiers in genetics · 2023Article
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- Helping behavior in prairie voles: A model of empathy and the importance of oxytocin.iScience · 2022Article
- Pair-bonding and social experience modulate new neurons survival in adult male and female prairie voles (Frontiers in neuroanatomy · 2022Article
- An epigenetic rheostat of experience: DNA methylation ofComprehensive psychoneuroendocrinology · 2021Review
- Oxytocin excites BNST interneurons and inhibits BNST output neurons to the central amygdala.Neuropharmacology · 2021Article
- Oxytocin, Dopamine, and Opioid Interactions Underlying Pair Bonding: Highlighting a Potential Role for Microglia.Endocrinology · 2021Review
- Genetic, epigenetic, and environmental factors controlling oxytocin receptor gene expression.Clinical epigenetics · 2021Article
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Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Social attachments are ubiquitous among humans and integral to human health. Although great efforts have been made to elucidate the neural underpinnings regulating social attachments, we still know relatively little about the neuronal and neurochemical regulation of social attachments. As a laboratory animal research model, the socially monogamous prairie vole (Microtus ochrogaster) displays behaviors paralleling human social attachments and thus has provided unique insights into the neural regulation of social behaviors. Research in prairie voles has particularly highlighted the significance of neuropeptidergic regulation of social behaviors, especially of the roles of oxytocin (OT) and vasopressin (AVP). This article aims to review these findings. We begin by discussing the role of the OT and AVP systems in regulating social behaviors relevant to social attachments, and thereafter restrict our discussion to studies in prairie voles. Specifically, we discuss the role of OT and AVP in adult mate attachments, biparental care, social isolation, and social buffering as informed by studies utilizing the prairie vole model. Not only do these studies offer insight into social attachments in humans, but they also point to dysregulated mechanisms in several mental disorders. We conclude by discussing these implications for human health. © 2017 American Physiological Society. Compr Physiol 7:81-104, 2017.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.