Evidence map›Paper›PMID 28134858›Full record

ArticleAntibiotics (Basel, Switzerland)2017

Docking into Mycobacterium tuberculosis Thioredoxin Reductase Protein Yields Pyrazolone Lead Molecules for Methicillin-Resistant Staphylococcus aureus.

Noreena L Sweeney, Lauren Lipker, Alicia M Hanson, Chris J Bohl, Katie E Engel, Kelsey S Kalous, Mary E Stemper, Daniel S Sem, William R Schwan

Open access · goldAbstract read
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Noreena L SweeneyDepartment of Pharmaceutical Sciences, Concordia University Wisconsin, 12800 N Lake Shore Dr, Mequon, WI 53097, USA. noreena.sweeney@cuw.edu.
Lauren LipkerDepartment of Microbiology, University of Wisconsin-La Crosse, La Crosse, WI 54601, USA. lipker.laur@uwlax.edu.
Alicia M HansonDepartment of Pharmaceutical Sciences, Concordia University Wisconsin, 12800 N Lake Shore Dr, Mequon, WI 53097, USA. alicia.schultz@cuw.edu.
Chris J BohlDepartment of Pharmaceutical Sciences, Concordia University Wisconsin, 12800 N Lake Shore Dr, Mequon, WI 53097, USA. chris.bohl@cuw.edu.
Katie E EngelDepartment of Microbiology, University of Wisconsin-La Crosse, La Crosse, WI 54601, USA. katieengel92@gmail.com.
Kelsey S KalousDepartment of Biochemistry, Medical College of Wisconsin, Wauwatosa, WI 53226, USA. kekalous@mcw.edu.
Mary E StemperMarshfield Clinic Research Foundation, Marshfield, WI 54449, USA. stemper.mary@marshfieldclinic.org.
Daniel S SemDepartment of Pharmaceutical Sciences, Concordia University Wisconsin, 12800 N Lake Shore Dr, Mequon, WI 53097, USA. Daniel.Sem@cuw.edu.
William R SchwanDepartment of Microbiology, University of Wisconsin-La Crosse, La Crosse, WI 54601, USA. wschwan@uwlax.edu.
Concordia University Wisconsin · USUniversity of Wisconsin–La Crosse · USMarshfield Clinic · USMedical College of Wisconsin · US

Funding

Targeting DUSP-5 to Treat Vascular AnomaliesR01HL112639 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI RAMCHANDRAN, RAMANI · 2012 to 2016
$2.6M
Development of ER-beta Agonists to Treat Post-Menopausal Memory DeclineR15GM118304 · NIGMS · CONCORDIA UNIVERSITY WISCONSIN · PI SEM, DANIEL S · 2015 to 2018
$820k
Structural Characterization of the M. tuberculosis Thioredoxin SystemR15AI101975 · NIAID · CONCORDIA UNIVERSITY WISCONSIN · PI SEM, DANIEL S · 2012 to 2012
$383k
NHLBI NIH HHS R01 HL112639NIAID NIH HHS R15 AI101975NIGMS NIH HHS R15 GM118304
6 · The paper itself

Abstract

The thioredoxin/thioredoxin reductase system (Trx/TrxR) is an attractive drug target because of its involvement in a number of important physiological processes, from DNA synthesis to regulating signal transduction. This study describes the finding of pyrazolone compounds that are active against

Indexed as

antibiotic targetenzyme inhibitormolecular dockingMRSApyrazolonesthioredoxin reductase

Identifiers

PMID28134858
PMCPMC5372984
OpenAlexW2579970834

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.