ArticleInternational journal of molecular sciences2017
Early Healing Events after Periodontal Surgery: Observations on Soft Tissue Healing, Microcirculation, and Wound Fluid Cytokine Levels.
Article in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- A systematic review of oral wound healing indices.PloS one · 2024Pooled it
- The effect of low-level laser therapy as an adjunct to periodontal surgery in the management of postoperative pain and wound healing: a systematic review and meta-analysis.Lasers in medical science · 2021Pooled it
- Comparative evaluation of hyaluronic acid spray and low-level laser therapy on wound healing following gingivectomy: a randomized controlled clinical trial.Lasers in medical science · 2026Trial
- CEMP-1 Levels in Periodontal Wound Fluid during the Early Phase of Healing: Prospective Clinical Trial.Mediators of inflammation · 2019Trial
- Fibroblast Growth Factor-2 and Enamel Matrix Derivative Enhance Proliferation, Migration, and Wound Healing in Gingival Epithelial and Fibroblast Cells.Medicina (Kaunas, Lithuania) · 2026Article
- Implementation, Validation and Clinical Testing of Oximetry Device for Microcirculation Assessment in Oral Tissue.Sensors (Basel, Switzerland) · 2025Article
- Biomarkers during early healing of extraction procedures: a prospective case series.Clinical oral investigations · 2025Article
- Single-cell sequencing systematically analyzed the mechanism of Emdogain on the restoration of delayed replantation periodontal membrane.International journal of oral science · 2025Article
- [Analysis of soft tissue healing after keratinized tissue augmentation in reconstructed jaws].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2025Article
- Introduction of "MAPS" wound healing index and its correlation with guided bone regeneration outcome.PloS one · 2025Article
- Non-invasive and quantitative methods for assessment of blood flow in periodontal and oral soft tissues: a systematic review.Frontiers in dental medicine · 2025Review
- Soft Tissue Retraction Maneuver in Cone Beam Computed Tomography Prior to Crown-Lengthening Procedure-A Technical Note.Journal of clinical medicine · 2024Article
- Microcirculation and neutrophil-related cytokine concentrations are not altered around narrow diameter implants in T2DM patients during wound healing.Clinical oral investigations · 2023Article
- Wound fluid sampling methods for proteomic studies: A scoping review.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2022Article
- Revisiting the vascularity of the keratinized gingiva in the maxillary esthetic zone.BMC oral health · 2021Article
- Post-periodontal surgery propounds early repair salivary biomarkers byMetabolomics : Official journal of the Metabolomic Society · 2019Article
- Comparative clinical evaluation of demineralized freeze-dried bone allograft (DFDBA) alone versus DFDBA with platelet-rich fibrin membrane in the management of intrabony defects: A step toward enhanced periodontal regeneration.National journal of maxillofacial surgeryArticle
- Platelet rich fibrin versus ozone gel for periodontal regeneration in induced rats' intrabony three-wall periodontal defects.Journal of oral biology and craniofacial researchArticle
- Effect of zirconia surface topography on epithelial attachment following diode laser-assisted crown lengthening: A controlled split-mouth animal study.Journal of oral biology and craniofacial researchArticle
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Early wound healing after periodontal surgery with or without enamel matrix derivative/biphasic calcium phosphate (EMD/BCP) was characterized in terms of soft tissue closure, changes of microcirculation, and expression of pro- and anti-inflammatory cytokines in gingival crevicular fluid/wound fluid (GCF/WF). Periodontal surgery was carried out in 30 patients (18 patients: application of EMD/BCP for regeneration of bony defects; 12 patients: surgical crown lengthening (SCL)). Healthy sites were observed as untreated controls. GCF/WF samples were collected during two post-surgical weeks. Flap microcirculation was measured using laser Doppler flowmetry (LDF). Soft tissue healing was evaluated after two weeks. GCF/WF levels of interleukin 1β (IL-1β), tumour necrosis factor (TNF-α), IL-6, and IL-10 were determined using a multiplex immunoassay. Surgery caused similar reductions of flap microcirculation followed by recovery within two weeks in both EMD/BCP and SCL groups. GCF/WF and pro-inflammatory cytokine levels were immediately increased after surgery, and returned only partially to baseline levels within the two-week observation period. Levels of IL-10 were temporarily reduced in all surgical sites. Flap dehiscence caused prolonged elevated levels of GCF/WF, IL-1β, and TNF-α. These findings show that periodontal surgery triggers an immediate inflammatory reaction corresponding to the early inflammatory phase of wound healing, and these inflammation measures are temporary in case of maintained closure of the flap. However, flap dehiscence causes prolonged inflammatory exudation from the periodontal wound. If the biological pre-conditions for periodontal wound healing are considered important for the clinical outcome, care should be taken to maintain primary closure of the flap.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.