ArticleScientia pharmaceutica2017
Natural Products as New Treatment Options for Trichomoniasis: A Molecular Docking Investigation.
Article in Scientia pharmaceutica, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 35 citations in OpenAlex.
- Candimine as a natural scaffold for targeting squalene synthetase in Trypanosoma cruzi: insights from computational studies.Molecular diversity · 2026Article
- Trichomonas vaginalis Drug Targets and Their Role in Drug Discovery and Development.Pharmaceutical research · 2026Review
- Novel Hit Compounds Against a Neglected Sexually Transmitted Infection: Synthesis and Trichomonacidal Activity of 1,3-Thiazolidin-4-One Derivatives.Pharmaceutics · 2026Article
- Anti-Pharmaceuticals (Basel, Switzerland) · 2025Article
- Antimicrobial Resistance in the Context of Animal Production and Meat Products in Poland-A Critical Review and Future Perspective.Pathogens (Basel, Switzerland) · 2024Review
- Bioprospection of the trichomonacidal activity of lipid extracts derived from marine macroalgae Gigartina skottsbergii.PloS one · 2023Article
- Chemical Composition and In Vitro and In Silico Antileishmanial Evaluation of the Essential Oil fromAntibiotics (Basel, Switzerland) · 2022Article
- Essential Oils as Antiviral Agents. Potential of Essential Oils to Treat SARS-CoV-2 Infection: AnInternational journal of molecular sciences · 2020Article
- Antiparasitic activity of furanyl N-acylhydrazone derivatives against Trichomonas vaginalis: in vitro and in silico analyses.Parasites & vectors · 2020Article
- 2'-Hydroxychalcones as an alternative treatment for trichomoniasis in association with metronidazole.Parasitology research · 2020Article
- Semi-synthesis, structural modification and biological evaluation of 5-arylbenzofuran neolignans.RSC advances · 2018Article
- Papain Loaded Poly(ε-Caprolactone) Nanoparticles: In-silico and In-Vitro Studies.Journal of fluorescence · 2018Article
- Review
- Phytochemical-rich foods inhibit the growth of pathogenic trichomonads.BMC complementary and alternative medicine · 2017Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Trichomoniasis, caused by the parasitic protozoan Trichomonas vaginalis, is the most common non-viral sexually-transmitted disease, and there can be severe complications from trichomoniasis. Antibiotic resistance in T. vaginalis is increasing, but there are currently no alternatives treatment options. There is a need to discover and develop new chemotherapeutic alternatives. Plant-derived natural products have long served as sources for new medicinal agents, as well as new leads for drug discovery and development. In this work, we have carried out an in silico screening of 952 antiprotozoal phytochemicals with specific protein drug targets of T. vaginalis. A total of 42 compounds showed remarkable docking properties to T. vaginalis methionine gamma-lyase (TvMGL) and to T. vaginalis purine nucleoside phosphorylase (TvPNP). The most promising ligands were polyphenolic compounds, and several of these showed docking properties superior to either co-crystallized ligands or synthetic enzyme inhibitors.
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Registered trials
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