Evidence map›Paper›PMID 28134774›Full record

ArticleInternational journal of molecular sciences2017

Deguelin Potentiates Apoptotic Activity of an EGFR Tyrosine Kinase Inhibitor (AG1478) in PIK3CA-Mutated Head and Neck Squamous Cell Carcinoma.

Yuh Baba, Toyonobu Maeda, Atsuko Suzuki, Satoshi Takada, Masato Fujii, Yasumasa Kato

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yuh BabaDepartment of General Clinical Medicine, Ohu University School of Dentistry, 31-1, Mitsumido, Tomita-machi, Koriyama City, Fukushima 963-8611, Japan. y-baba@den.ohu-u.ac.jp.
Toyonobu MaedaDepartment of Oral Function and Molecular Biology, Ohu University School of Dentistry, 31-1, Mitsumido, Tomita-machi, Koriyama City, Fukushima 963-8611, Japan. t-maeda@den.ohu-u.ac.jp.
Atsuko SuzukiDepartment of Oral Function and Molecular Biology, Ohu University School of Dentistry, 31-1, Mitsumido, Tomita-machi, Koriyama City, Fukushima 963-8611, Japan. at-suzuki@den.ohu-u.ac.jp.
Satoshi TakadaDepartment of Oral and Maxillofacial Surgery, Ohu University School of Dentistry, 31-1, Mitsumido, Tomita-machi, Koriyama City, Fukushima 963-8611, Japan. s-takada@den.ohu-u.ac.jp.
Masato FujiiNational Institute of Sensory Organs, National Tokyo Medical Center, 2-5-1, Higashigaoka, Meguro, Tokyo 152-8902, Japan. fujiimasato@kankakuki.go.jp.
Yasumasa KatoDepartment of Oral Function and Molecular Biology, Ohu University School of Dentistry, 31-1, Mitsumido, Tomita-machi, Koriyama City, Fukushima 963-8611, Japan. yasumasa-kato@umin.ac.jp.
Ohu University · JPTokyo Medical Center · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Head and neck squamous cell carcinoma (HNSCC) is known to be intrinsically resistant to inhibitors for epidermal growth factor receptor (EGFR). Until now, clinical outcomes for HNSCC using EGFR inhibitors as single agents have yielded disappointing results. Here, we aimed to study whether combinatorial treatment using AG1478 (EGFR tyrosine kinase inhibitor) and deguelin, which is a rotenoid isolated from the African plant

Indexed as

ApoptosisCarcinoma, Squamous CellCell Line, TumorClass I Phosphatidylinositol 3-KinasesDrug SynergismErbB ReceptorsExtracellular Signal-Regulated MAP KinasesHead and Neck NeoplasmsHumansMutant ProteinsMutationPhosphatidylinositol 3-KinasesPhosphorylationProtein Kinase CProtein Kinase InhibitorsQuinazolinesClass I Phosphatidylinositol 3-KinasesdeguelinErbB ReceptorsExtracellular Signal-Regulated MAP KinasesMutant ProteinsPhosphatidylinositol 3-KinasesPIK3CA protein, humanProtein Kinase CProtein Kinase InhibitorsQuinazolinesRotenoneRTKI cpdTyrphostinsAKTdeguelinepidermal growth factor receptor (EGFR)head and neck squamous cell carcinoma (HNSCC)PIK3CA

Identifiers

PMID28134774
PMCPMC5343798
OpenAlexW2581581719

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.