Evidence map›Paper›PMID 28134524›Full record

ArticleThe journal of physical chemistry. B2017

Monod-Wyman-Changeux Analysis of Ligand-Gated Ion Channel Mutants.

Tal Einav, Rob Phillips

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of physical chemistry. B, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Tal EinavDepartment of Physics, California Institute of Technology , Pasadena, California 91125, United States.ORCID 0000-0003-0777-1193
Rob PhillipsDepartment of Applied Physics and Division of Biology and Biological Engineering, California Institute of Technology , Pasadena, California 91125, United States.ORCID 0000-0003-3082-2809

Funding

The Principles of Regulatory, Conformational and Evolutionary AdaptationR35GM118043 · NIGMS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI ROB PHILLIPS · 2016 to 2026
$7.9M
NIH Director's Pioneer Award (RMI)DP1OD000217 · OD · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI PHILLIPS, ROB · 2004 to 2008
$4.0M
Biophysical, Structural and Functional Analysis of Mechanosensitive ChannelsR01GM084211 · NIGMS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI HASWELL, ELIZABETH S, PHILLIPS, ROB · 2008 to 2016
$3.6M
Single-Molecule and Single-Cell Analysis of Transcription Factor-DNA ComplexesR01GM085286 · NIGMS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI PHILLIPS, ROB · 2009 to 2015
$2.8M
NIGMS NIH HHS R01 GM084211NIGMS NIH HHS R01 GM085286NIGMS NIH HHS R35 GM118043NIH HHS DP1 OD000217
6 · The paper itself

Abstract

We present a framework for computing the gating properties of ligand-gated ion channel mutants using the Monod-Wyman-Changeux (MWC) model of allostery. We derive simple analytic formulas for key functional properties such as the leakiness, dynamic range, half-maximal effective concentration ([EC

Indexed as

MutationBinding SitesHumansModels, BiologicalMutant ProteinsReceptors, NicotinicThermodynamicsMutant ProteinsReceptors, Nicotinic

Identifiers

PMID28134524
PMCPMC5551692

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.