Evidence map›Paper›PMID 28134317›Full record

ArticleScientific reports2017

Genomic and structural investigation on dolphin morbillivirus (DMV) in Mediterranean fin whales (Balaenoptera physalus).

Giorgia Beffagna, Cinzia Centelleghe, Giovanni Franzo, Giovanni Di Guardo, Sandro Mazzariol

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Giorgia BeffagnaDepartment of Comparative Biomedicine and Food Science, University of Padua, Padua, Italy.
Cinzia CentellegheDepartment of Comparative Biomedicine and Food Science, University of Padua, Padua, Italy.
Giovanni FranzoDepartment of Animal Medicine, Production and Health, University of Padua, Padua, Italy.
Giovanni Di GuardoUniversity of Teramo, Faculty of Veterinary Medicine, Teramo, Italy.
Sandro MazzariolDepartment of Comparative Biomedicine and Food Science, University of Padua, Padua, Italy.
University of Padua · ITUniversity of Teramo · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dolphin morbillivirus (DMV) has been deemed as one of the most relevant threats for fin whales (Balaenoptera physalus) being responsible for a mortality outbreak in the Mediterranean Sea in the last years. Knowledge of the complete viral genome is essential to understand any structural changes that could modify virus pathogenesis and viral tissue tropism. We report the complete DMV sequence of N, P/V/C, M, F and H genes identified from a fin whale and the comparison of primary to quaternary structure of proteins between this fin whale strain and some of those isolated during the 1990-'92 and the 2006-'08 epidemics. Some relevant substitutions were detected, particularly Asn52Ser located on F protein and Ile21Thr on N protein. Comparing mutations found in the fin whale DMV with those occurring in viral strains of other cetacean species, some of them were proven to be the result of diversifying selection, thus allowing to speculate on their role in host adaptation and on the way they could affect the interaction between the viral attachment and fusion with the target host cells.

Indexed as

Genome, ViralGenomicsAmino Acid SequenceAnimalsBase SequenceFin WhaleGenes, ViralImaging, Three-DimensionalModels, MolecularMorbillivirusNucleic Acid ConformationPhylogenyProtein BindingProtein ConformationRNA, ViralWhole Genome SequencingRNA, Viral

Identifiers

PMID28134317
PMCPMC5278511
OpenAlexW2580241229

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.