ArticleNature communications2017
Bacillus subtilis biofilm extends Caenorhabditis elegans longevity through downregulation of the insulin-like signalling pathway.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
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Who cites it
66 citing papers in PubMed.
- Biofilm overproduction enhances gastrointestinal stress tolerance and intestinal fitness inGut microbes · 2026Article
- Article
- Metabolic shifts driven by host-microbial interactions.The FEBS journal · 2026Review
- Aging regulation by gut microbiota: molecular insights from Caenorhabditis elegans.Biogerontology · 2026Review
- Host Oxidative Response Capacity Determines Longevity Outcomes of Microbial Interventions.Aging cell · 2026Article
- Multi-Model Longevity Assays Reveal Lifespan- and Healthspan-Promoting Effects ofMicroorganisms · 2026Article
- Discovering a green pesticide candidate for controlling bacterial plant disease: 1,2,3,4-tetrahydro-β-carboline as a potential biofilm inhibitor.RSC advances · 2025Article
- Bacillus subtilis TO-A suppresses the age-related decline in locomotion in Caenorhabditis elegans.Communications biology · 2025Article
- Structure-activity relationship of ginsenoside derivatives with different glycosides and double bond position on anti-aging bioactivities.Journal of ginseng research · 2025Article
- Master of Puppets: How Microbiota Drive the Nematoda Ecology and Evolution?Ecology and evolution · 2025Review
- MitigatingBiofilm · 2025Article
- Evaluation of ProbioticMicroorganisms · 2025Article
- Antiaging Effect of 2-Foods (Basel, Switzerland) · 2025Article
- Biofilm proficient Bacillus subtilis prevents neurodegeneration in Caenorhabditis elegans Parkinson's disease models via PMK-1/p38 MAPK and SKN-1/Nrf2 signaling.Scientific reports · 2025Article
- The soil Mycobacterium sp. promotes health and longevity through different bacteria-derived molecules in Caenorhabditis elegans.Aging cell · 2025Article
- Behavioral adaptations ofPeerJ · 2025Review
- Identification of antagonistic activity againstFrontiers in microbiology · 2025Article
- Harnessing gut microbiota for longevity: Insights into mechanisms and genetic manipulation.iMetaOmics · 2024Article
- Article
- Bacterial peptidoglycan acts as a digestive signal mediating host adaptation to diverse food resources in C. elegans.Nature communications · 2024Article
6 more citing papers are in PubMed but not listed here.
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7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Beneficial bacteria have been shown to affect host longevity, but the molecular mechanisms mediating such effects remain largely unclear. Here we show that formation of Bacillus subtilis biofilms increases Caenorhabditis elegans lifespan. Biofilm-proficient B. subtilis colonizes the C. elegans gut and extends worm lifespan more than biofilm-deficient isogenic strains. Two molecules produced by B. subtilis - the quorum-sensing pentapeptide CSF and nitric oxide (NO) - are sufficient to extend C. elegans longevity. When B. subtilis is cultured under biofilm-supporting conditions, the synthesis of NO and CSF is increased in comparison with their production under planktonic growth conditions. We further show that the prolongevity effect of B. subtilis biofilms depends on the DAF-2/DAF-16/HSF-1 signalling axis and the downregulation of the insulin-like signalling (ILS) pathway.
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