ArticleProceedings of the National Academy of Sciences of the United States of America1989
Prostaglandins with antiproliferative activity induce the synthesis of a heat shock protein in human cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 170 citations in OpenAlex.
- Early detection and progression of insulin resistance revealed by impaired organismal anti-inflammatory heat shock response during ex vivo whole-blood heat challenge.Clinical science (London, England : 1979) · 2025Article
- Heat shock response during the resolution of inflammation and its progressive suppression in chronic-degenerative inflammatory diseases.Cell stress & chaperones · 2024Review
- Regulation of stress signaling pathways by protein lipoxidation.Redox biology · 2019Review
- Optimal dose of PG600 when given to progestogen-synchronized ewes during anestrus as affected by day of the year and temperature.Translational animal science · 2019Article
- PGA1-induced apoptosis involves specific activation of H-Ras and N-Ras in cellular endomembranes.Cell death & disease · 2016Article
- The cyclopentenone prostaglandin 15d-PGJ2 inhibits the NLRP1 and NLRP3 inflammasomes.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- The heat shock protein response following eccentric exercise in human skeletal muscle is unaffected by local NSAID infusion.European journal of applied physiology · 2013Article
- A survey of marine natural compounds and their derivatives with anti-cancer activity reported in 2010.Molecules (Basel, Switzerland) · 2011Review
- Induction of the 72-kilodalton heat shock protein and protection from ultraviolet B-induced cell death in human keratinocytes by repetitive exposure to heat shock or 15-deoxy-delta(12,14)-prostaglandin J2.Cell stress & chaperones · 2006Article
- Heat shock protein 70 is related to thermal inhibition of nuclear export of the influenza virus ribonucleoprotein complex.Journal of virology · 2004Article
- The cyclopentenone prostaglandin 15-deoxy-delta(12,14)- PGJ2 attenuates the development of colon injury caused by dinitrobenzene sulphonic acid in the rat.British journal of pharmacology · 2003Article
- Inhibition of cellular proliferation through IkappaB kinase-independent and peroxisome proliferator-activated receptor gamma-dependent repression of cyclin D1.Molecular and cellular biology · 2001Article
- The chaperone function of hsp70 is required for protection against stress-induced apoptosis.Molecular and cellular biology · 2000Article
- Inactivation of wild-type p53 tumor suppressor by electrophilic prostaglandins.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Induction of heat shock protein 70 by herbimycin A and cyclopentenone prostaglandins in smooth muscle cells.Cell stress & chaperones · 2000Article
- Antiviral effect of hyperthermic treatment in rhinovirus infection.Antimicrobial agents and chemotherapy · 1999Article
- Localization of a cyclopentenone prostaglandin to the endoplasmic reticulum and induction of BiP mRNA.The Biochemical journal · 1998Article
- Inhibition of nuclear factor kappa B by prostaglandin A1: an effect associated with heat shock transcription factor activation.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Inhibition of HIV-1 replication by cyclopentenone prostaglandins in acutely infected human cells. Evidence for a transcriptional block.The Journal of clinical investigation · 1996Article
- Inhibition of poliovirus replication by prostaglandins A and J in human cells.Antimicrobial agents and chemotherapy · 1996Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prostaglandins (PGs) A1 and J2 were found to potently suppress the proliferation of human K562 erythroleukemia cells and to induce the synthesis of a 74-kDa protein (p74) that was identified as a heat shock protein related to the major 70-kDa heat shock protein group. p74 synthesis was stimulated at doses of PGA1 and PGJ2 that inhibited cell replication, and its accumulation ceased upon removal of the PG-induced proliferation block. PGs that did not affect K562 cell replication did not induce p74 synthesis. p74 was found to be localized mainly in the cytoplasm of PG-treated cells, but moderate amounts were found also in dense areas of the nucleus after PGJ2 treatment. p74 synthesis was not necessarily associated with cytotoxicity or with inhibition of cell protein synthesis. The results described support the hypothesis that synthesis of the 70-kDa heat shock proteins is associated with changes in cell proliferation. The observation that PGs can induce the synthesis of heat shock proteins expands our understanding of the mechanism of action of these compounds whose regulatory role is well known in many physiological phenomena, including the control of fever production.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.