ArticleProceedings of the National Academy of Sciences of the United States of America1989
Molecular cloning and sequence analysis of 3-hydroxy-3-methylglutaryl-coenzyme A reductase from the human parasite Schistosoma mansoni.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Computational and experimental exploration of statin and statin-like compounds as potential treatment of schistosomiasis.PLoS neglected tropical diseases · 2025Article
- Adults from Kisumu, Kenya have robust γδ T cell responses to Schistosoma mansoni, which are modulated by tuberculosis.PLoS neglected tropical diseases · 2020Article
- Gamma delta T cells in non-immune patients during primary schistosomal infection.Immunity, inflammation and disease · 2014Article
- Chemical and genetic validation of the statin drug target to treat the helminth disease, schistosomiasis.PloS one · 2014Article
- Characterization of potential drug targets farnesyl diphosphate synthase and geranylgeranyl diphosphate synthase in Schistosoma mansoni.Antimicrobial agents and chemotherapy · 2013Article
- Analysis of Schistosoma mansoni genes shared with Deuterostomia and with possible roles in host interactions.BMC genomics · 2007Article
- Immunological evidence for eight spans in the membrane domain of 3-hydroxy-3-methylglutaryl coenzyme A reductase: implications for enzyme degradation in the endoplasmic reticulum.The Journal of cell biology · 1992Article
- Article
- Amino acid substitution matrices from an information theoretic perspective.Journal of molecular biology · 1991Article
- A spliced leader is present on a subset of mRNAs from the human parasite Schistosoma mansoni.Proceedings of the National Academy of Sciences of the United States of America · 1990Article
- Regulation of HMG-CoA reductase: identification of the site phosphorylated by the AMP-activated protein kinase in vitro and in intact rat liver.The EMBO journal · 1990Article
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Authors and funding
4 authors.
Funding
Abstract
cDNA clones encoding the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase [(S)-mevalonate:NADP+ oxidoreductase (CoA-acylating), EC 1.1.1.34] from the human parasite Schistosoma mansoni have been isolated and characterized. The composite 3459 base pairs of cDNA sequence contains a 2844-base-pair open reading frame corresponding to a protein of 948 amino acids. The predicted S. mansoni HMG-CoA reductase protein contains a hydrophobic amino terminus consisting of seven potential transmembrane domains that are structurally conservative but are not identical in amino acid sequence with HMG-CoA reductases from other species. The hydrophilic carboxyl terminus of the S. mansoni HMG-CoA reductase protein, however, shares 48-52% sequence identity with the carboxyl termini of other HMG-CoA reductases in a region that contains the catalytic domain. When expressed as a fusion protein in Escherichia coli, the carboxyl-terminal domain of the schistosome protein exhibits HMG-CoA reductase enzyme activity.
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