Evidence map›Paper›PMID 28133804›Full record

ReviewImmunological reviews2017

Immunologic characteristics of HIV-infected individuals who make broadly neutralizing antibodies.

Persephone Borrow, M Anthony Moody

Open access · hybridAbstract readReview
In one paragraph

Review in Immunological reviews, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 49 citations in OpenAlex.

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  12. ImmunoHorizons · 2020
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Persephone BorrowNuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.
M Anthony MoodyDuke University Human Vaccine Institute and Departments of Pediatrics and Immunology, Duke University School of Medicine, Durham, NC, USA.
Duke University · USUniversity of Oxford · GB

Funding

Virus biology scientific research support componentUM1AI100645 · NIAID · DUKE UNIVERSITY · PI MCMICHAEL, ANDREW JAMES · 2012 to 2018
$204.7M
Medical Research Council MR/K012037/1NIAID NIH HHS UM1 AI100645
6 · The paper itself

Abstract

Induction of broadly neutralizing antibodies (bnAbs) capable of inhibiting infection with diverse variants of human immunodeficiency virus type 1 (HIV-1) is a key, as-yet-unachieved goal of prophylactic HIV-1 vaccine strategies. However, some HIV-infected individuals develop bnAbs after approximately 2-4 years of infection, enabling analysis of features of these antibodies and the immunological environment that enables their induction. Distinct subsets of CD4

Indexed as

AIDS VaccinesAnimalsAntibodies, NeutralizingB-LymphocytesGerminal CenterHIV-1HIV AntibodiesHIV InfectionsHumansImmunity, HumoralImmunologic MemoryT-Lymphocyte SubsetsAIDS VaccinesAntibodies, NeutralizingHIV Antibodiesautoantibodybroadly neutralizing antibodyCD4+ T follicular helper cellCD4+ T follicular regulatory cellhuman immunodeficiency virusregulatory T cell

Identifiers

PMID28133804
PMCPMC5299500
OpenAlexW2583015103

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.