Evidence map›Paper›PMID 28133791›Full record

ArticleJournal of clinical laboratory analysis2017

The effect of different protease inhibitors on stability of parathyroid hormone, insulin, and prolactin levels under different lag times and storage conditions until analysis.

Ozgur Baykan, Ali Yaman, Fethullah Gerin, Onder Sirikci, Goncagul Haklar

Open access · bronzeAbstract read
In one paragraph

Article in Journal of clinical laboratory analysis, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Ozgur BaykanClinical Biochemistry, Ataturk State Hospital, Balikesir, Turkey.
Ali YamanClinical Biochemistry, Marmara University School of Medicine, Istanbul, Turkey.ORCID http://orcid.org/0000-0001-5659-5195
Fethullah GerinClinical Biochemistry, Central Laboratory of Public Health, Istanbul, Turkey.
Onder SirikciClinical Biochemistry, Marmara University School of Medicine, Istanbul, Turkey.
Goncagul HaklarClinical Biochemistry, Marmara University School of Medicine, Istanbul, Turkey.
Marmara University · TRBalıkesir University · TRIstanbul Eye Hospital · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionProteolytic cleavage through proteases affects peptide hormone levels, which is of particular significance when the time interval between sampling and analysis is prolonged. We evaluated the stability of parathyroid hormone, insulin, and prolactin molecules (i) with different protease inhibitors such as K MATERIALS AND

methodsBlood samples were collected into 2 sets of 5 Vacutainer

resultsInsulin at RT decreases exceeding the DBL starting from 24 hours and K

conclusionsDifferent proteases may degrade peptide hormones and measures should be taken to counteract these effects especially if there is a delay before analysis.

Indexed as

AdultBlood Specimen CollectionFemaleHumansImmunoassayInsulinMaleParathyroid HormoneProlactinProtease InhibitorsProtein StabilityYoung AdultInsulinParathyroid HormoneProlactinProtease Inhibitorsinsulinparathyroid hormonepre-analytical phaseprolactinprotease inhibitors

Identifiers

PMID28133791
PMCPMC6817059
OpenAlexW2583013614

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.