Trial reportThe Journal of physiology2017
Refuting the myth of non-response to exercise training: 'non-responders' do respond to higher dose of training.
Trial report in The Journal of physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 2 registered trials, which are not on this map. Cited by 167 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effects of Low-Volume High Intensity Interval Training and Circuit Training on Maximal Oxygen Uptake
Improving Individual Glycemic Response With Exercise Intensity
Who cites it
167 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Changes in Cardiorespiratory Fitness Following Exercise Training Prescribed Relative to Traditional Intensity Anchors and Physiological Thresholds: A Systematic Review with Meta-analysis of Individual Participant Data.Sports medicine (Auckland, N.Z.) · 2025Pooled it
- Standard Deviation of Individual Response for VOSports medicine (Auckland, N.Z.) · 2024Pooled it
- Effect of Hypoxia Conditioning on Body Composition in Middle-Aged and Older Adults: A Systematic Review and Meta-Analysis.Sports medicine - open · 2023Pooled it
- The relationship between hemoglobin andPloS one · 2023Pooled it
- Pooled it
- Sex Dimorphism of VOSports medicine (Auckland, N.Z.) · 2019Pooled it
- Prehabilitation before major intra-abdominal cancer surgery: A systematic review of randomised controlled trials.European journal of anaesthesiology · 2019Pooled it
- Impact of resistance and endurance exercise training on femoral artery function: sex differences in humans.The Journal of physiology · 2025Trial
- Cardiorespiratory Fitness Improvements Following Low-Frequency Training Are Not Inferior to High-Frequency Training Matched for Intensity and Volume.Scandinavian journal of medicine & science in sports · 2025Trial
- Machine Learning-Driven Phenogrouping and Cardiorespiratory Fitness Response in Metastatic Breast Cancer.JCO clinical cancer informatics · 2024Trial
- Hypotensive effects of exercise training: are postmenopausal women with hypertension non-responders or responders?Hypertension research : official journal of the Japanese Society of Hypertension · 2024Trial
- Strength gains after 12 weeks of resistance training correlate with neurochemical markers of brain health in older adults: a randomized controlGeroScience · 2023Trial
- Endurance versus resistance training in treatment of cardiovascular risk factors: A randomized cross-over trial.PloS one · 2022Trial
- Trial
- Individual cardiovascular responsiveness to work-matched exercise within the moderate- and severe-intensity domains.European journal of applied physiology · 2021Trial
- Intra-individual physiological response of recreational runners to different training mesocycles: a randomized cross-over study.European journal of applied physiology · 2020Trial
- Enhanced physical and cognitive performance in active duty Airmen: evidence from a randomized multimodal physical fitness and nutritional intervention.Scientific reports · 2020Trial
- Trial
- GLP-1 secretion is regulated by IL-6 signalling: a randomised, placebo-controlled study.Diabetologia · 2020Trial
- Personalized Moderate-Intensity Exercise Training Combined with High-Intensity Interval Training Enhances Training Responsiveness.International journal of environmental research and public health · 2019Trial
107 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Commented on by
- Commented on by
- Erratum issuedCorrigendum.2018
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
key pointsThe prevalence of cardiorespiratory fitness (CRF) non-response gradually declines in healthy individuals exercising 60, 120, 180, 240 or 300 min per week for 6 weeks. Following a successive identical 6-week training period but comprising 120 min of additional exercise per week, CRF non-response is universally abolished. The magnitude of CRF improvement is primarily attributed to changes in haemoglobin mass. The potential for CRF improvement may be present and unveiled with appropriate exercise training stimuli in healthy individuals without exception. ABSTRACT: One in five adults following physical activity guidelines are reported to not demonstrate any improvement in cardiorespiratory fitness (CRF). Herein, we sought to establish whether CRF non-response to exercise training is dose-dependent, using a between- and within-subject study design. Seventy-eight healthy adults were divided into five groups (1-5) respectively comprising one, two, three, four and five 60 min exercise sessions per week but otherwise following an identical 6-week endurance training (ET) programme. Non-response was defined as any change in CRF, determined by maximal incremental exercise power output (W
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.