Evidence map›Paper›PMID 28133728›Full record

ArticleInternational journal of cancer2017

Weight and weight changes in early adulthood and later breast cancer risk.

Bernard Rosner, A Heather Eliassen, Adetunji T Toriola, Wendy Y Chen, Susan E Hankinson, Walter C Willett, Catherine S Berkey, Graham A Colditz

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 5 pooled it
6.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 5 syntheses or guidelines pooled it, 123 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Bernard RosnerChanning Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115.ORCID 0000-0001-6907-0056
A Heather EliassenChanning Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115.
Adetunji T ToriolaSiteman Cancer Center and Washington University School of Medicine, Saint Louis, MO, 63110.
Wendy Y ChenChanning Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115.
Susan E HankinsonChanning Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115.
Walter C WillettChanning Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115.
Catherine S BerkeyChanning Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115.
Graham A ColditzSiteman Cancer Center and Washington University School of Medicine, Saint Louis, MO, 63110.
Brigham and Women's Hospital · USWashington University in St. Louis · US

Funding

Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ROSNER, BERNARD A · 2000 to 2019
$77.8M
Long Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3M
Sleep Duration, Childhood Energy Balance, and Insulin Resistance in AdolescenceU54CA155626 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI STAMPFER, MEIR · 2011 to 2015
$9.6M
Worksite Policies and neighborhood Influences on Obesity and Cancer RiskU54CA155496 · NCI · WASHINGTON UNIVERSITY · PI COLDITZ, GRAHAM A. · 2011 to 2016
$9.0M
NCI NIH HHS P01 CA087969NCI NIH HHS U54 CA155496NCI NIH HHS U54 CA155626NCI NIH HHS UM1 CA186107
6 · The paper itself

Abstract

Obesity is a well-established cause of postmenopausal breast cancer. However, early life adiposity is inversely associated with breast cancer incidence. To understand these conflicting relations, we use validated measures to assess adiposity in childhood and late adolescence, as well as weight change, in relation to total invasive breast cancer incidence and receptor subtypes. We conducted a prospective observational study among 74,177 women from the Nurses' Health Study from 1980-2012, with updated risk factors every 2 years during which 4,965 incident invasive breast cancers occurred. Overall, weight at age 18 was inversely associated with both premenopausal (HR per 30 kg = 0.52, 95% CI = 0.39-0.71) and postmenopausal (HR per 30 kg = 0.81, 95% CI = 0.72-0.92) breast cancer which was largely explained by adiposity at age 10. Long-term weight gain from age 18 both during premenopause and postmenopause were positively associated with postmenopausal breast cancer risk. However, premenopausal weight gain was not related to premenopausal breast cancer risk. Furthermore, weight gain since age 18 was positively associated with ER+/PR+ postmenopausal breast cancer (HR per 30 kg = 1.50, 95% CI = 1.36-1.65) but not ER+/PR- (HR per 30 kg = 0.96, 95% CI = 0.78-1.19) or ER-/PR- (HR per 30 kg = 1.16, 95% CI = 0.95-1.42) postmenopausal breast cancer. Overall, 17% of ER+/PR+ postmenopausal breast cancer and 14% of total postmenopausal breast cancer are attributable to weight gain of > 5 kg since age 18.

Indexed as

Weight GainAdiposityAdolescentAdultAgedBreast NeoplasmsEstrogen Receptor alphaFemaleHumansMiddle AgedObesityPostmenopausePremenopauseProgesteroneProspective StudiesReceptors, ProgesteroneESR1 protein, humanEstrogen Receptor alphaProgesteroneReceptors, Progesteroneestrogen receptorobesitypre-adolescent adiposityprogesterone receptorweight gain

Identifiers

PMID28133728
PMCPMC5798241
OpenAlexW2583099408

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.